Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Jim-Ray Chen, M.D., Ph.D.

Attending Physician
National Institute of Cancer Research


Ph.D., Experimental Pathology, McGill University, Montreal, Quebec, Canada, 1995
M.D., School of Medicine, Taipei Medical College, Taiwan,1988


- Attending Physician, National Institute of Cancer Research, National Health Research Institutes, Taiwan
- Attending Physician, Department of Anatomic Pathology, Chang Gung Memorial Hospital, Linkou, Taiwan
- Postdoctoral Training, Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick Cancer and Research Development Center, Frederick, MD, USA
- Postdoctoral Training, Department of Pathology, Montreal General Hospital, Montreal, Quebec, Canada
- Pre-doctoral Training, program in Experimental Pathology, McGill University, Montreal, Quebec, Canada


Dr. Chen's research interests include several areas including (1) development and validation of diagnostic and prognostic biomarkers of soft tissue sarcomas; (2) development of cost-effective and efficient methodologies for high-throughput validation of biomarkers; (3) characterization of hereditary colorectal cancer syndrome and (4) establishment of tissue microarray program.


Dr. Chen's lab has established efficient and reproducible protocols of molecular analyses of formalin-fixed, paraffin-embedded sections, and has applied these techniques for various studies including molecular diagnoses of tumors with specific gene translocations, viral diseases and gene expression studies. This lab also established standard operating procedures for immunohistochemistry and provided high-throughput automated immunohistochemical staining. They also established core histopathology facilities for routine tissue processing and pathologic examinations for clinical and animal studies.


  1. Chen J-R**, J. M. Chiang**, C. R. Changchien, J. S. Chen, R. Tang, J. Y. Wang Mismatch repair gene expressions in Amsterdam II Criteria-positive kindreds in Taiwanese population and their relation to the clinical features. British Journal of Surgery (accepted for publication, ** equal contribution)
  2. Chen, CK, Hseuh C, Lai, JY, Hung, IJ, Whang-Peng J, Wang, WP, Lai, HY, Chen J-R*. Renal cell carcinoma with t(X;17)(p11.2;q25) in a 6-year-old Taiwanese boy. Virchows Archiv, Published online December 6, 2006.
  3. You JF, Hsieh LL, Changchien CR, Chen JS, Chen J-R, Chiang JM, Sheih PS, Fan CW, Liu CT and Tang RP. Inverse effects of mucin on survival of matched hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer patients. Clin Cancer Res 12:4244-4250, 2006
  4. Chiang JM, Changchien CR and Chen J-R*. Solitary rectal ulcer syndrome: an endoscopic and histological presentations and literature review. Int J Colorectal Dis 21: 348-356, 2006.
  5. Cheng JG, Chen J-R, Hernandez, Alvord WG and Stewart CL. Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation. Proc Natl Acad Sci USA 98(15):8650-8585, 2001.
  6. Chen J-R, Cheng JG, Shatzer T, Sewell L, Hernandez L and Stewart CL. Leukemia inhibitory factor can substitute for nidatory estrogen and is essential to inducing a receptive uterus for implantation but is not essential subsequent embryogenesis. Endocrinology 141(12):4365-72, 2000.
  7. Chen J-R, Tsao M-S, and Duguid WP. Hepatocytic differentiation of propagable cultured rat pancreatic ductal cells following in vivo implantation. Am J Pathology 147: 707-717, 1995.
    (* = Corresponding Author)