Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Yi-Rong Chen, Ph.D.

Associate Investigator
Institute of Molecular and Genomic Medicine


- Ph.D., Department of Microbiology and Immunology, Baylor College of Medicine, USA, 1998
- M.S., Institute of Microbiology and Immunology, National Yang-Ming Medical College, Taiwan, 1991
- B.S., Department of Medical Technology, College of Medicine, National Taiwan University, Taiwan, 1989


  • Assistant Investigator (2003-2008) & Associate Investigator (2008-present), Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan
  • Assistant Professor, Department of Immunology, Baylor College of Medicine, Houston, Texas,USA (2002-2003)
  • Postdoctoral Associate, Baylor College of Medicine, Houston, Texas, USA (1998-2002)
  • Research Assistant, Institute of Biomedical Science, Academia Sinica, Taiwan (1993-1994)
  • Research Assistant, Veterans General Hospital, Taipei, Taiwan (1990-1991)
  • Training student, Institute of Biomedical Science, Academia Sinica, Taiwan (1988-1989)


    Dr. Chen's research interests are cell signaling pathways activated by stress stimulation and by growth factor receptors. His laboratory works on the aberrant cell signaling and oncogenesis induced by mutated EGF receptor. Dr. Chen also studies the roles of novel protein phosphatases in regulation of receptor tyrosine kinase signaling.


    Dr. Chen has authored 21 research articles and two invited review articles. His works on the involvement of JNK in apoptotic signaling are highly cited (more than a thousand times) by other researchers. He is a reviewer for journals including Molecular Pharmacology, Carcionogenesis, Cancer Letters, and Journal of Biomedical Science.


  • Travel award, Keystone Symposium; NIH Grant #1 R13 CA85280-01 (2000)
  • Postdoctoral fellowship, Prostate Cancer Research Program, Department of Defense, USA (1999-2002)
  • Alexander Wang Memorial Scholarship, SCBA-Texas Chapter Symposium (1998)
  • Predoctoral fellowship, Breast Cancer Research Program, Department of Defense, USA (1997-1999)
  • Dean's award, Graduate School, Baylor College of Medicine (1997-1998)
  • Platform presentation award, Graduate Student Symposium, Baylor College of Medicine, Houston (1997)
  • Travel award, Keystone Symposium; provided by NIH (1996)
  • Outstanding Student Scholarship, National Yang-Ming Medical College, Taiwan (1990-1991)
  • Book Coupon Awards, National Taiwan University, Taiwan (1986-1989)


    1. W.-H. Lin, J.-S. Song, T.-Y. Chang, C.-Y. Chang, Y.-N. Fu, C.-L. Yeh, S.-H. Wu, Y.-W. Huang, M.-Y. Fang, T.-W. Lien, H.-P. Hsieh, Y.-S. Chao, S.-F. Huang, S.-F. Tsai, L.-M. Wang, J. T.-A. Hsu, Y.-R. Chen. A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors. Anal. Biochem., 377: 89-94, 2008

    2. Y.-N. Fu, C.-L. Yeh, H. H.-Y. Cheng, C.-H. Yang, S.-F. Tsai, S.-F. Huang, Y.-R. Chen. EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy. Oncogene, 27: 957-965, 2008.

    3. J.-Y. Wang, C.-H. Lin, C.-H. Yang, T.-H. Tan, and Y.-R. Chen. Biochemical and biological characterizations of a neuroendocrine-associated phosphatase (NEAP). J. Neurochem., 98: 89-101, 2006

    4. Y.-R. Chen, Y.-N. Fu, C.-H. Lin, S.-T. Yang, S.-F. Hu, Y.-T. Chen, S.-F. Tsai, and S.-F. Huang. Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants. Oncogene, 25: 1205-1215, 2006

    5. Y.-R. Chen, J. Han, R. Kori, and T.-H. Tan. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J. Biol. Chem., 277: 39334-39342, 2002

    6. Y.-R. Chen, A. Shrivastava, and T.-H. Tan. Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate. Oncogene, 20: 367-374, 2001