Su-Fang Lin, Ph.D.
National Institute of Cancer Research
- Ph.D., Microbiology, National Taiwan University, Taiwan, 1995
- M.S., Microbiology, National Taiwan University, Taiwan, 1989
- B.S., Medical Technology, National Yang-Ming University, Taiwan 1987
- Assistant Investigator, Institute of Cancer Research, National Health Research Institutes, Taiwan (2007-present)
- Assistant Investigator, Division of Clinical Research, National Health Research Institutes, Taiwan (2003-2007)
- Assistant Research Biochemist, Biological Chemistry, University of California, Davis, USA (1999-2003)
- Postdoctoral Fellow, Molecular Biology and Microbiology, CWRU, USA (1997-1999)
- Postdoctoral Fellow, Molecular Biophysics and Biochemistry, Yale University, USA (1995-1996)
RESEARCH INTERESTSDr. Lin's laboratory is directed at studying the oncogenic mechanisms of human herpes virus including EBV and KSHV. EBV has been linked to seven types of cancer and KSHV is closely associated with three. It is not completely understood why only the minority of EBV or KSHV infected individuals suffered from cancers, while the majority can be waived. It is mysterious why most of the reported EBV and KSHV encoded onco-proteins are not expressed in vivo, while emerging data indicate that lytic replication of EBV or KSHV, which presumably leads to cell death, is required in viral pathogenesis. Finally, comparative genomic studies have revealed significant identities between EBV and KSHV, thus it is intriguing to catalogue the common pathways by which these two oncogenic herpes virus employ to induce various cancers, and to find interventions that counteract them.
RESEARCH ACTIVITIES & ACCOMPLISHMENTSMolecularly, the latent-lytic conversion of EBV or KSHV latent genome is controlled by an immediate-early transcription factor, designated as RTA (replication and transcription activator). To understand how RTA works and how RTA's own expression being regulated, the lab is actively working on (1) expression profiling of the host genes modulated by RTA; (2) roles of phosphorylation and O-GlcNAcylation in the biological functions of RTA; and (3) cell cycle progression and RTA expression.
HONORS & AWARDS
- Universitywide AIDS Research Program Postdoctoral Fellowship, University of California, USA, 1999
- Dr. Chien-Tien Hsu's Award, 1995
- Member of Phi Tau Phi Scholastic Honor Society, 1993
- Izumiya Y, Lin SF, Ellison TJ, Levy AM, Mayeur GL, Izumiya C and Kung HJ. Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest. J Virol, 77:9652-61, 2003.
- Izumiya Y, Lin SF, Ellison T, Chen LY, Izumiya C, Luciw P and Kung HJ. Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression. J Virol, 77:1441-51, 2003.
- Lin SF, Robinson DR, Oh J, Jung JU, Luciw PA and Kung HJ. Identification of the bZIP and Rta homologues in the genome of rhesus monkey rhadinovirus. Virology, 298:181-8, 2002.
- Parcells MS, Lin SF, Dienglewicz RL, Majerciak V, Robinson DR, Chen HC, Wu Z, Dubyak GR, Brunovskis P, Hunt HD, Lee LF and Kung HJ. Marek's disease virus (MDV) encodes an interleukin-8 homolog (vIL-8): characterization of the vIL-8 protein and a vIL-8 deletion mutant MDV. J Virol, 75:5159-73, 2001.
- Robinson DR, Wu YM and Lin SF. The protein tyrosine kinase family of the human genome. Oncogene, 19:5548-57, 2000.