Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Ching-Chuan Liu, M.D., M.P.H.

Joint-appointed Investigator
Division of Infectious Diseases


-M.P.H., Public Health, Johns Hopkins University, USA
-M.D., Medicine, National Taiwan University, Taiwan


- Joint-appointed Investigator, Division of Clinical Research, National Health Research Institutes, Taiwan (2003-present)
- Professor of Pediatrics and Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Taiwan
- Director, Department of Pediatrics, College of Medicine, National Cheng Kung University, Taiwan
- Director, Center for Infection Control, National Cheng Kung University Hospital, Taiwan


Dr. Liu's research interests included: seroepidemiologic study of vaccine-preventable diseases, hospital epidemiology and health-care associated infections, pathogenesis of dengue virus infection, pathogenesis of enteroviral infections, and study on the virulence factors in group A streptococcal infections.


During the 1998 epidemic of enterovirus 71 infection in Taiwan, Dr. Liu and his colleague were the first to isolated and identify the causative pathogen was EV71, and published their clinical and laboratory findings in well-known scientific journals including New England Journal of Medicine, Clinical Infectious Diseases, Journal of Infectious Diseases, Pediatrics. He also collaborated with the faculty of the Department of Microbiology and Immunology in the research of the immunopathogenesis of dengue virus infection, and has published more than 20 scientific papers in this field. Overall, he has had over 120 scientific publications.


1. Mei-Chih Huang, Shih-Min Wang, Yung-Wen Hsu, Hui-Chen Lin, Chia-Yu Chi, Ching-Chuan Liu*. Long-term cognitive and motor deficits following enterovirus 71 brainstem encephalitis in children. Pediatrics.118: 1785-88, 2006.
2. Shih-Min Wang, Huan-Yao Lei, Mei-Chih Huang, Ling-Yao Su, Hui-Chen Lin, Chun-Keung Yu, Jung-Lung Wang, Ching-Chuan Liu*. Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis. J Clin Virol. 37:47-52, 2006.
3. Chia-Yu Chi, Shih-Min Wang, Hui-Chen Lin, Ching-Chuan Liu*. A clinical and microbiological comparison of Staphylococcus aureus toxic shock and scaled skin syndromes in children. Clin Infect Dis. 42:181-185, 2006.
4. Shih-Min Wang, Huan-Yao Lei, Mei-Chih Huang, Jing-Min Wu, Chun-Ta Chen, Jieh-Neng Wang, Jen-Ren Wang, Ching-Chuan Liu*. The therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema. Pediatr Pulm. 39:219-23, 2005.
5. Shih-Min Wang, Huan-Yao Lei, Kao-Jean Huang, Jing-Ming Wu, Jen-Ren Wang, Chun-Keung Yu, Ih-Jen Su, Ching-Chuan Liu*. Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: the roles of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis. 188:564-70, 2003.
6. Chao-Ching Huang, Ching-Chuan Liu, Ying-Chao Chang, Cheng-Yu Chen, Shan-Tair Wang, Tsu-Fuh Yeh. A clinical spectrum of acute neurological complications of enterovirus 71 infection. New Engl J Med. 341:936-42, 1999.
7. Shih-Min Wang, Ching-Chuan Liu*, Hui-Wan Tseng, Jen-Ren Wang, Chao-Ching Huang, Yung-Jung Chen, Yao-Jong Yang, Shio-Jean Lin, Tsu-Fuh Yeh. Clinical spectrum of enterovirus 71 infection of children in southern Taiwan, with an emphasis on neurological complications. Clin Infect Dis. 29:184-90, 1999.
(* = Corresponding author)