Jing-Jou Yan, M.D.
Joint-appointed Assistant Investigator
Division of Infectious Diseases
EDUCATIONM.D., Medicine, National Yang-Ming Medical School, Taipei, Taiwan
PROFESSIONAL EXPERIENCES- Joint-appointed Assistant Investigator, Division of Clinical Research, National Health Research Institutes, Taiwan
- Attending Physician, National Cheng Kung University Hospital, Taiwan
- Research Fellow, Department of Laboratory Medicine, School of Medicine, Yale University, USA
RESEARCH INTERESTSAntimicrobial resistance is a matter of great concern worldwide and has caused serious therapeutic problems in bacterial infections in Taiwan. Consistent and persistent surveillance of resistant bacteria is one of the most important measures in preventing the emergence and spread of novel drug-resistant mechanisms. Dr. Yan is interested in understanding the prevalence and mechanisms of antimicrobial resistance in human pathogenic bacteria and how the resistance mechanisms were spread in Taiwan. He has been focusing on the molecular epidemiology of novel resistance mechanisms, such as ?-lactamases conferring resistance to extended-spectrum cephalosporins and carbapenems.
RESEARCH ACTIVITIES & ACCOMPLISHMENTSDr. Yan's team have identified many novel important drug-resistant mechanisms in gram-negative bacilli for the first time in Taiwan. For β-lactamases that can confer resistant to extended-spectrum cephalosporins, they identified IMP-1, VIM-2, VIM-3, and IMP-8 metallo-β-lactamases, plasmid-mediated CMY-2, CMY-8, and DHA-1 AmpC-type cephalosporinsases, and CTX-M and SHV-12-type extended-spectrum &bata;-lactamases. They described firstly the emergence of ceftriaxone-resistant Salmonella isolates and then the emergence of Salmonella isolates resistant to both extended-spectrum cephalosporins and fluoroquinolones in Taiwan. Moreover, the team established the link between CMY-2-producing human isolates and food animals isolates in Taiwan, indicating food animals in husbandry in Taiwan are important reservoirs of drug-resistant mechanisms. For aminoglycoside-resistant mechanisms, they detected the emergence of ArmA and RmtB 16S rRNA methylases, which can confer high-level resistance to most aminoglycosides, in Enterobacteriaceae.
SELECTED PUBLICATIONS1.Wu JJ, Chen HM, Ko WC, Wu HM, Tsai SH and Yan JJ*. Prevalence of extended-spectrum ?-lactamases in Proteus mirabilis in a Taiwanese university hospital, 1999 to 2005: identification of a novel CTX-M enzyme (CTX-M-66). Diagn. Microbiol. Infect. Dis., 2008 (in press).
2.Wu JJ, Ko WC, Tsai SH, Yan JJ*. Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital. Antimicrob. Agents Chemother., 51:1223-1227, 2007.
3.Yan JJ, Hsueh PR, Lu JJ, Chang FY, Ko WC and Wu JJ. Characterization of acquired beta-lactamases and their genetic support in multidrug-resistant Pseudomonas aeruginosa isolates in Taiwan: the prevalence of unusual integrons. J. Antimicrob. Chemother., 58:530-536, 2006.
4.Yan JJ, Chiou CS, Lauderdale TL, Tsai SJ and Wu JJ. Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan. Emerg. Infect. Dis., 11:947-950, 2005.
5.Yan JJ, Wu JJ, Ko WC, Tsai SH, Chuang CL, Wu HM, Lu YJ and Li JD. Plasmid-mediated 16S rRNA methylases conferring high-level aminoglycoside resistance in Escherichia coli and Klebsiella pneumoniae isolates from two Taiwanese hospitals. J. Antimicrob. Chemother., 54:1007-1012, 2004.
6.Yan JJ, Ko WC, Chiu CH, Tsai SH, Wu HM and Wu JJ. Emergence of ceftriaxone-resistant Salmonella isolates and rapid spread of plasmid-encoded CMY-2Ślike cephalosporinase, Taiwan. Emerg. Infect. Dis., 9:323-328, 2003.