Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Dennis Hsieh, Sc.D.

Investigator & Acting Director
Division of Environmental Health and Occupational Medicine
dphsieh@nhri.org.tw

EDUCATION

Diploma, Academic Administration University of California, Irvine, California, 1983.
Diploma, General Toxicology Massachusetts Institute of Technology, Cambridge, 1979.
Sc.D., Biochemical Engineering Massachusetts Institute of Technology, 1969.
M.S., Biochemical Engineering, Massachusetts Institute of Technology, 1967.
Graduate Study in Plant Nutrition and Biochemistry, Utah State University, Logan, 1965.
B.A., Agricultural Chemistry, National Taiwan University, Taipei, 1959.

PROFESSIONAL EXPERIENCES

- Investigator and Acting Director, Division of Environmental Health & Occupational Medicine, National Health Research Institutes, Taiwan (2006 - 2007)
- Investigator, Division of Environmental Health & Occupational Medicine, National Health Research Institutes, Taiwan (2004-2006)
- Visiting Professor, Graduate Program in Atmospheric, Maine, and Costal Environment, the Hong Kong University of Science and Technology, Hong Kong (2001-2003)
- Professor & Head, Department of Biology, the Hong Kong University of Science and Technology, Hong Kong (1997-2001)
- Visiting Professor, Department of Biology, the Hong Kong University of Science and Technology, Hong Kong (1995-1996)
- Professor, Department of Environmental Toxicology, University of California, Davis, USA (1980-1994)
- Professor & Chairman, Department of Environmental Toxicology, University of California, Davis, USA (1983-1988)
- Assistant Biochemical Engineer, Assistant Professor, Associate Professor, University of California, Davis, USA (1969-1980 )

RESEARCH INTERESTS

Dr. Hsieh's research interests are listed as follows:
- Environmental toxicology and health risk assessment of chemicals and infectious agents.
Health risk assessment of imported beef from BSE infected countries.
- Identification and prioritization of environmental risk factors associated with female lung adenocarcinoma in Taiwan.
- Environmental health studies on heavy metals in farm soils in Changhua County, Taiwan.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Bringing along his research and teaching experience in the last 30 years, Dr. Hsieh quickly established a research team to generate laboratory data for assessing the health risk of microcystins in drinking water, aflatoxin M1 in fresh milk and paralytic shellfish toxins in seafood to the general public in Taiwan. Data indicated that these three classes of environmental chemicals are not of great concern. He then launched on two on-going projects and became the PI of a special NHRI project on the environmental health studies on the high levels of toxic heavy metals in farm soils in Changhua County and a national genomic research program on lung cancer focused on toxicogenomic studies on female lung adenocarcinoma in Taiwan. The Changhua project has led to the observation that the heavy metals in soil did not constitute a major risk factor related to deaths due to any forms of cancer. The toxicogenomic project has helped to set up a battery of rapid methods for chemical characterization and toxicity evaluation for components in cooking oil fumes, motorcycle emissions and environmental tobacco smokes. In 2005 Dr. Hsieh was asked by NHRI to organize and lead a risk science team to endeavor on research and manpower training in response to the needs of several government agencies. The health risk assessment of beef imported from USA has provided a scientific basis for the Department of Health in its decision to lift the ban on USA beef importation. His team are at present conducting a similar assessment of beef from Canada, another BSE infected country. They are at present also teaching a 32-hour course on the practice of health risk assessment to the Taiwan Agricultural Chemical and Toxicological Research Institute. Based on this course, NHRI is contemplating the establishment of a training and certification program to help training the staffs of various agencies for conducting health risk assessment of agents of their respective interests. By these endeavors, NHRI will be directly involved in meeting the urgent national needs in assessing the health risks of many environmental pollutants to set their remediation goals. In August 2006, Dr. Hsieh began to serve as Acting Director of the Division of Environmental Health and Occupational Medicine. Among the first things he did was to integrate divisional research endeavors to concentrate on just a few focal areas. One of which is epidemiological and toxicological research leading toward improved health risk assessment and risk reduction.

SELECTED PUBLICATIONS

Referreed journal articles (total 137)

1 Wang CH, Ho AYT, Qian PY, Wong PK, Hsieh DPH (2004) Antibiotic treatment enhances C2 toxin production by Alexandrium tamarense in batch cultures. Harmful Algae 3:21-28.
2 Li AMY, Yu PKN, Hsieh DPH, Wang W-X, Wu RSS and Lam PKS (2005) Uptake and depuration of paralytic shellfish toxins in the green-lipped mussel, Perna viridis: a dynamic model. Environmental Toxicology and Chemistry 24:129-35.
3 Wang DZ, Jiang TJ, Hsieh DPH (2005) Toxin composition variations in cultures of Alexandrium species isolated from the coastal waters of southern China. Harmful Algae 4: 109-121.
4 Li CM, Chu RY, Hsieh DPH (2006) An enhanced LC-MS/MS method for microcystin-LR in lake water. J Mass Spectrom. 41:169-74.
5 Chan LL, Sit WH, Hsieh DPH, et al. (2006) Identification and characterization of a ‘biomarker of toxicity” from the proteome of the paralytic shellfish toxin-producing dinoflagellate Alexandrium tamarense (Dinophyceae). Proteomics 6: 654-666.
6 Choi NMC, Yeung LWY, Hsieh DPH, et al. (2006) Relationships between tissue concentrations of paralytic shellfish toxins and antioxidative responses of clams, Ruditapes philippinarum. Marine Pollution Bulletin; 52: 572-597.
7 Choi MC, Yu PKN, Hsieh DPH, et al. (2006) Trophic transfer of paralytic shellfish toxins from clams (Ruditapes philippinarum) to gastropods (Nassarius festivus). Chemosphere 64: 1642-1649.
8 Chang FH, Wang HJ, Hsieh DPH, et al. (2006) Survey of urinary nickel in residents of areas with a high density of electroplating factories. Chemosphere 65: 1723-1730.
9 Chiang PH, Hsieh DPH, Chen HH, et al. (2006) Identification of soil contamination in AnShen using geographic information system. Taiwan Journal of Public Health 5:363-371.

Referreed risk assessment documents and project reports(total 23)

1. Hsieh DPH (2006) Health risk assessment of consumption of beef imported from USA. Report submitted to the R.O.C. Department of Health.
2. Hsieh DPH (2006) Assessment of health risk due to consumption of beef imported from Canada. Preliminary report submitted to R.O.C. Department of Health.

Proceedings and book chapters(total 42)



1. Hsieh DPH, Chou IC, Wang YC, Wang SJ, Chang LW, Wang SL, Wu KY. Questions on the health risks of high levels of heavy metals found in farm soils in Changhua County. Taiwan Association of Soil and Groundwater Environmental Protection Symposium on Risk Assessment, Management, and Communication, Taipei, Taiwan, January 2006

2. Hsieh DPH, Assessment of health risk due to consumption of beef imported from USA. 21st ROC-US Bilateral Modern Economic and Technological Symposium, Taipei, Taiwan, September 2006.