Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Chung-Shi Yang, Ph.D.

Distinguished Investigator and Director
Center for Nanomedicine Research
cyang@nhri.org.tw;cyang@ncnu.edu.tw

EDUCATION

Ph.D. in Chemistry,
The Pennsylvania State University (1991)

PROFESSIONAL EXPERIENCES

Member of Consulting Committee, Chemistry Division, Department of Natural Sciences and Mathematics, National Science Council, Taipei, Taiwan (2006-present)
Panelist, Chemistry Division, Department of Natural Sciences and Mathematics, National Science Council, Taipei, Taiwan (2003-2005)
Consultant, Industrial Technology and Research Institute (ITRI), Hsinchu, Taiwan (2003- 2005)
Adjunct Professor, Department of Engineering and System Science, National Tsing-Hua University, Hsinchu, Taiwan (2003-present)
Professor, Department of Applied Chemistry, National Chi-Nan University, Puli, Taiwan (2000-present)
Founding Director, Graduate Institute of Biomedicine and Biomedical Technology, National Chi-Nan University, Puli, Taiwan (2003-2005)
Chairperson, Department of Applied Chemistry, National Chi-Nan University, Puli, Taiwan (2001-2004)
Visiting Scholar, Department of Chemistry, Stanford University, CA, U.S.A. (sponsored by National Science Council, Taiwan, hosted by Professor Richard N. Zare) (1999-2000)

RESEARCH INTERESTS

Dr. Yang's research interests are listed as follows:
  • Nanoparticles in basic medicine research clinical diagnosis/therapeutics, particularly in non-invasive imaging, targeted drug delivery and controlled release.
  • Mechanistic studies and clinical applications of transdermal delivery/sampling
  • Implantable -device for minimally invasive sampling and/or in situ analysis to study various physiological disorders
  • Implantable micro-device for in vivo and in situ biomedical analysis
  • Damage mechanisms and therapeutic approaches of organ ischemia and reperfusion: such as stroke, acute myocardial infarction and liver ischemia/reperfusion

Dr. Yang focuses on conducting interdisciplinary researches, through collaborations whose effort combine the methodologies of chemical, physical, biological sciences and engineering, on exploring life science phenomena and mechanisms: from the molecular and cellular levels to the integrated and systemic levels.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Chung Shi Yang endeavors to coordinate multidisciplinary research. He has published more than fifty peer-reviewed papers in international journals, and has been invited as a speaker in numerous international conferences or events. He also has been invited to serve as panel or reviewer in many important institutes and committees, such as National Science Council, Taiwan.

Dr. Yang's accomplishments are shown in both research and administrative. From 1997 to 2000, Dr. Yang was respectively the owner of Shih-Chun Wang Young Investigator Award (by Chinese Neuroscience Society of Taiwan), Tsing-Ling Yen Medical Research Award (by Chinese Medicine Association of Taiwan), Distinguished Young Chemists Award (by Chinese Chemistry Society of Taiwan), and Distinguished Young Chemist Award of the Federation of Asian Chemical Societies (by the Federation of Asian Chemical Societies). In 2003, he completed the establishment of Graduate Institute of Biomedicine and Biomedical Technology, National Chi-Nan University, and was appointed as the Founding Director. At the meantime, Dr. Yang successfully coordinated a joint research program for Taichung Veterans General Hospital and National Chi-Nan University.

In 2004, Dr. Yang was appointed as the Director of Center for Nanomedicine Research/NHRI to integrate research in physics, chemistry, material science and engineering towards the application of nanoscience and nanotechnology to the prevention and treatment of human diseases, through intramural and extramural collaborative activities. Under Dr. Yang's instruction, CNMR will be playing an important share of the collective efforts to promote the Nanoscience and Nanotechnology development in Taiwan.

SELECTED PUBLICATIONS

1. Hsiao, H. Y.; Mak, O. T.; Yang, C. S. Liu, Y.P.; Fang, K.M.; Tzeng, S. F. TNF-α/IFN-γ-Induced iNOS Expression Increased by Prostaglandin E2 in Rat Primary Astrocytes via EP2-Evoked cAMP/PKA and Intracellular Calcium Signaling.(in press).

2. Hunag, D. M.; Hung, Y.; Ko, B. S.; Hsu, S. C.; Chen, W. H.; Chien, C. L.; Tsai, C. P.; Kuo, C. T.; Kang, J. C.; Yang, C. S.; Mou, C. Y.; Chen, Y. C. Highly efficient cellular labeling of mesoporous nanoparticles in the human mesenchymal stem cells: implication for stem cell tracking. FASEB J 19:2014-2016, 2005.

3. Tsai, P. J.; Chen, W. Y.; Tzeng, S. F.; Liang, W. M..; Yang, C. S. Experimental spinal cord injury induced an increase of extracellular ascorbic acid concentration in anesthetized rats: A microdialysis study. Clin Chim Acta 362:94-100, 2005.

4. Lo, L. W.; Tsai, P. J.; Huang, H. Y.; Wang, Y. T.; Chang, C. H.; Yang, C. S. In vivo monitoring of fluorescent nanosphere delivery in anesthetized rats using an implantable fiber-optic microprobe Anal Chem 77: 1125-1131, 2005.

5. Yang, C. S.; Chang, C. H.; Tsai, P. J.; Chen, W. Y.; Lo, L . W. Nanoparticle-based in vivo investigations on blood brain barrier permeability following ischemia and reperfusion. Anal Chem 76:4465-4471, 2004.