Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Wen-Shiang Chen, Ph.D.

Joint-appointed Assistant Investigator
Division of Medical Engineering Research


-Ph.D., Department of Bioengineering, University of Washington
-M.D., Department of Medicine, National Taiwan University


-Assistant Professor and Attending Physician: Department of Physical Medicine and Rehabilitation, National Taiwan University Medical College and Hospital (2003- present)
-Adjunct Assistant Professor: Department of Mechanical Engineering , National Taiwan University (2004-present )
-Adjunct Assistant Investigator: Division of Medical Engineering Research, National Health Research Institutes (2004-present)
-Research Associate: Department of Mechanical Engineering and Material Science, Duke University (2002-3)
-Research Assistant : Applied Physics Laboratory, University of Washington (1998- 2002)
-Resident Physician: Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital (1993-7)


Dr. Chen's research interests concentrate on various aspects of therapeutic use of ultrasound, including ultrasound mediated gene transfection and drug delivery, physical mechanisms of ultrasound and shockwave on therapy, ultrasound contrast agents and the cavitation related bioeffects, intravascular ultrasound catheter for thrombolysis, and high intensity focused ultrasound (HIFU) for tumor ablation. Dr. Chen is also interested in the therapeutic mechanisms of different physical modalities used in his current department such as shortwave, electrical therapy and traction.


Dr. Chen has authored almost 30 original research articles during his Ph.D. study and the three-year research work after graduation. He is also a reviewer for several journals including IEEE UFFC, JOR, etc.


  1. Contrast-enhanced ultrasound thermal ablation, Tung, Y.S., Liu, H.L., Ju, K.C., Chen, W.S. and Lin, W.L., Ultrasound in Medicine and Biology, Vol.32 (7): 1103-1110, 2006
  2. Differences in the lesion formation process between focused ultrasound and microwave ablations, Chen, W.S., Wu, C.C., Fang, H.Y. and Liu, H.L., J. Med. Phy., Vol. 38(5): 1346-1351, 2006
  3. A novel method for estimating the focal size of two confocal high-intensity focused ultrasound transducers, Chen, W.S., Ma, P.M., Liu, H.L., Yeh, C.K., Chen, M.S., Chang, C.W., J. Acoustic Society of America, Vol.117(6), pp. 3740-3749, 2005.
  4. The effect of surface agitation on ultrasound-mediated gene transfer in vitro, Chen, W.S., Lu, X., Liu, Y. and Zhong, P., J. Acoustic Society of America, Vol.116(4), pp. 2240-2250, 2004.
  5. The pulse length dependence of inertial cavitation dose and hemolysis: Chen, W.S., Brayman, A.A., Matula, T.J., Crum, L.A. and Miller, M.W., Ultrasound in Medicine and Biology, Vol. 29(5), pp.739-748, 2003.
  6. Inertial cavitation dose and hemolysis produced in vitro with or without Optison: Chen, W.S., Brayman, A.A., Matula, T.J. and Crum, L.A., Ultrasound in Medicine and Biology, Vol. 29(5), pp.729-737, 2003.
  7. A comparison of the fragmentation thresholds and inertial cavitation doses of different ultrasound contrast agents: Chen, W.S., Matula, T.J., Brayman, A.A. and Crum, L.A., J. Acoustic Society of America, Vol.113(1), pp.643-651, 2003.