Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Ling-Jun Ho, Ph.D.

Assistant Investigator
Institute of Cellular and Systems Medicine
lingjunho@nhri.org.tw

EDUCATION

  • Ph.D., Life Science, National Defense Medical Center, Taiwan
  • M.Sc., Microbiology and Immunology, National Defense Medical Center, Taiwan
  • B.Sc., Microbiology, Soo Chow University, Taiwan

    PROFESSIONAL EXPERIENCES

    - Assistant Investigator, Division of Gerontology Research, National Health Research Institutes, Taipei, Taiwan (2003 - present)
    - Assistant Professor, Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan (2002 - 2003)
    - Post-doctoral training, Immunology, Department of Medicine, Tri-Service General Hospital, Taiwan (2001-2003)
    - Research Technician, Department of Urology, MD Anderson Cancer Center, Houston, Texas, USA (1993-1997)
    - Lecturer, Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan (1986-1993)

    RESEARCH INTERESTS

    Dr. Ho's research interests are focused on investigating the role of inflammation in the pathogenesis of osteoarthritis. The therapeutic potential and mechanisms of several anti-inflammatory drugs in osteoarthritis were also examined both in vitro and in vivo. In addition, following her post-doctor studies, Dr. Ho also actively participate several inflammation-related studies such as dengue virus infection in human dendritic cells and the examination of the immunomodulatory effects and mechanisms of Chinese anti-inflammatory drugs. These ongoing studies cover many different fields involving molecular, cellular and animal aspects.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Ho published more than 23 original SCI publications in the field of microbiology and immunology. She started her research career in the field of gerontology since she joined the division of Gerontology of NHRI in 2003. Their research group already published a paper which suggest that vitamin A may protect OA patients from pro-inflammatory cytokine-mediated damage of chondrocytes and their supporting matrixes via blocking p38 kinase activity and JNK-AP1 signaling (Ho et al., Biochemical Pharmacology 2005 15;70:200-8). Currently, they actively participate in studying the chondroprotective effect of several potential immunomodulatory drugs, testing both in vitro and in vivo models. The influence of collagen glycation on the the chondrocyte activity and their possible role in leading to the occurrence of osteoarthritis is another research project they are interested in . In addition, Dr. Hos lab. set up research cooperation with other disciplines including pharmacologist and clinical physician to span the breadth and depth of their research.

    SELECTED PUBLICATIONS


    1. Ho L.-J., Lin L.-C., Hung L.-F., Wang S.-J., Lee C.-H., Chang D.-M., Lai J.-H.** and T.-Y. Tai. Retinoic acid blocks proinflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes. Biochemical Pharmacology. 15(70):200-8, 2005.
    2. Ho L.-J., Hung L.-F., Weng C.-Y., Chang D.-M., Chou P, Wu W.-L., Lin Y.-L., Tai T.-Y. and J.-H. Lai**. Dengue virus antagonizes IFN-a but not IFN-g anti-viral effect via down-regulating Tyk2-STAT signaling in human dendritic cell. Journal of Immunology. 174:8163-8172, 2005.
    3. Ho L.-J., Shiao M.-F., Chang D.-M., Liao C.-L., and J.-H., Lai. Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines. Immunological Investigation. 33:423-37, 2004.
    4. Ho L.-J., Juan T.-Y., Chao P., Wu W.-L., Chang D.-M., Chang S.-Y. and J.-H. Lai**. Plant alkaloid tetrandrine down-regulates IkBa kinases-IkBa-NF-kB signaling pathway in human peripheral blood T cell. British Journal of Pharmacology.143:919-927, 2004.
    5. Cheng S.-M., Yang S.-P., Ho L.-J., Tsao T.-P., Chang D.-M., and J.-H. Lai**. Irbesartan Inhibits Human T-lymphocyte Activation Through Down-Regulation of Activator Protein-1. British Journal of Pharmacology. 142:933-942, 2004.
    6. Yang S.-P., Ho L.-J., Cheng S.-M., Hsu Y.-L., Tsao T.-P., Chang D.-M., and J.-H., Lai. Carvediol differentially regulates cytokine production from activated human peripheral blood mononuclear cells. Cardiovascular Drugs Therapy. 18: 183-8, 2004.
    7. Ho, L.-J. and J.-H. Lai. Immunomodulatory effects and mechanisms of traditional Chinese herbs as potential disease-modifying antirheumatic drugs in autoimmune diseases. Current Drug Metabolism. 5:181-92, 2004.