Chia-Hsiang Chen, M.D., Ph.D.
Institute of Population Health Sciences
EDUCATIONPh.D., City University of New York, USA
B.M., College of Medicine, National Yang-Ming University, Taiwan
PROFESSIONAL EXPERIENCES- 2008- Professor, Department of Psychiatry and Institute of Human Genetics, Tzu-Chi University, Hualien CIity, Taiwan, R.O.C.
- 2005-2007. Investigator and Associate Director, Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Zhunan, Taiwan, R.O.C.
- 2000-Present Professor, Department of Psychiatry and Institute of Human Genetics, Tzu-Chi University, Hualien City, Taiwan, R.O.C.
- 1998-2005 Director of Department of Psychiatry, Tzu-Chi General Hospital, Hualien, Taiwan, R.O.C.
- 1998-2000 Associate Professor of Department of Psychiatry and Institute of Human Genetics, Tzu-Chi University, Hualien City, Taiwan, R.O.C.
- 1994-98 Associate Professor, Department of Neuropsychiatry, National Yang-Ming University, Taipei, Taiwan, R.O.C.
- 1983-89 Resident of Psychiatry, Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan, R.O.C.
RESEARCH INTERESTSDr. Chen is interested in solving the genetic puzzles of some major mental disorders such as schizophrenia, autism and mental retardation, so he can help elucidate the pathogenesis of these major mental disorders. He is also interested in studying the molecular mechanism of drugs that affect the mental status, such as psychostimulants and antipsychotic drugs. He hopes he can identify the common pathway of these psychoactive drugs, so he can develop better treatment for patients suffering from severe mental disorders.
RESEARCH ACTIVITIES & ACCOMPLISHMENTSDr. Chen has been engaging in identifying susceptibility genes of schizophrenia using systemic genetic approaches, such as cytogenetic analysis, comparative genome hybridization analysis and case-control association study. He has established a collaborative team consisting of psychiatrists, cytogeneticists, molecular geneticists and statisticians to carry out systematic investigation. Recently, he extends his team to help study the genetic underpinnings of autism and mental retardation by collaborating with child psychiatrists and pediatricians. In addition, he also applies the functional genomics methodology such as microarray analysis of gene expression profiling and proteomics to study molecular mechanism of psychoactive drugs. He has identified several differentially expressed genes in the brain under long-term administration of antipsychotic drugs. These findings may shed some lights on the molecular mechanism of antipsychotic drugs and may help develop new drugs in the future.
SELECTED PUBLICATIONS1. Chen ML, Chen CH (corresponding author). Chronic antipsychotics treatment regulates MAOA, MAOB and COMT gene expression in rat frontal cortex. J Psychiatr Res 2007;41:57-62.
2. Chen ML, Chen CH (corresponding author). Comparative proteome analysis revealed up-regulation of transthyretin in rat brain under chronic clozapine treatment. J Psychiatr Res 2007; 41:63-68.
3. Cheng MC, Chen CH (corresponding author). Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia. J Psychiatr Res 2007?41:1027-31.
4. Chen SF, Chen JY, Wang YC, Lai IC, Liou YJ, Liao DL, Chen CH (corresponding author). Support for association of the A277C single nucleotide polymorphism in human vesicular monoamine transporter 1 gene with schizophrenia. Schizophr Res 2007; 90:363-5.
5. Shen YC, Chen SJ, Lin CC, Chen CH. Concomitant use of lamotrigine and aripiprazole increases risk of Stevens-Johnson syndrome? Int Clin Psychopharmacol. 2007; 22:247-8.
6. Shen YC, Haw-Ming L, Lin CC, Chen CH. Psychosis in a patient with Fabry's disease and treatment with aripiprazole. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31:779-80.
7. Shen YC, Lee MY, Lin CC, Chen CH. Orally disintegrating olanzapine for the treatment of a manic patient with esophageal stricture plus chronic pharyngitis. Prog Neuropsychopharmacol Biol Psychiatry. 2007?31:541-2.
8. Cheng MC, Liao DL, Hsiung CA, Chen CY, LiaoYC, Chen CH (corresponding author). Chronic treatment with aripiprazole induces differential gene expression in rat frontal cortex. Int J Neuropsychopharmacol 2007 Sep 17:1-10 [Epub ahead of print]
9. Fang JS, Chen CH. (corresponding author). Chromosomal abnormalities and gene discovery in schizophrenia. Taiwanese J Psychiatry 2007?21:242-253.
10. Luu SU, Liao HM, Hung TW, Liu BY, Cheng MC, Liao DL, Chen SJ, Chen CH (corresponding author). Adenosine A2a receptor gene and dopamine D2 receptor gene in schizophrenia. Psychiatr Genet 2008 (in press).
11. Wang LH, Chen JY, Wang YC, Lai IC, Liou YJ, Liao DL, Chen SF, Chen CH (corresponding author). Variants of the PRKC, Apoptosis, WT1, regulator gene (PAWR) are associated with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2008 (in press).