Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Feng-Shiun Shie, Ph.D.

Assistant Investigator
Institute of Population Health Sciences


- Ph.D., University of Washington, Seattle, WA, U.S.A., 2000
- M.S., Florida International University, Miami, FL, U.S.A.,1995
- B.S., Fu-Jen University, Taipei, Taiwan, 1988


- 2000-2005 Senior Fellow/Acting Instructor, Division of Neuropathology, Department of Pathology, University of Washington School of Medicine, Seattle, Washington.
- 2005-present Assistant Investigator, Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Zhunan, Taiwan.


The research of Dr. Shie focuses on pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Niemann Pick type C disease. Dr. Shie's research interests include functions of microglial innate immunity and glia-neuron interaction in the disease. Therapeutic targeting for neurodegenerative diseases is the ultimate goal of his research.


Dr. Shie was trained at Alzheimer's Disease Research Center at University of Washington for researches in neurodegenerative diseases and return to home country in the end of 2005. He has established a research record on neurodegenerative diseases with 16 peer-viewed publication and 1 US patent in the recent 5 years. The major focus of Dr. Shie's research in NHRI is to understand the regulatory mechanisms of the glia-neuron interactions in the pathogenesis of Alzheimer's diseases and to gain insights into the roles of prostanoid pathways and PPAR


1. Feng-Shiun Shie and Randall L. Woltjer. Manipulating microglial activation as a therapeutic strategy for Alzheimer's disease. Current Medicinal Chemistry. 2007; 14(27): 2865-2871. IF: 5.2

2. Feng-Shiun Shie and Zaodung Ling. Therapeutic strategy at the crossroad of neuroinflammation and oxidative stress in age-related neurodegenerative diseases. Expert Opin Ther Pat. 2007;17(4):419-428. IF: 1.5

3. Jinghua Jin, Feng-Shiun Shie, Jun Liu, Yan Wang, Jeanne Davis, Aimee M Schantz, Kathleen S Montine, Thomas J Montine and Jing Zhang. Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein. J Neuroinflammation. 2007;4:2:1-10. IF:4.4

4. Randall L. Woltjer, Wendy McMahan, Dejan Milatovic, John D. Kjerulf, Feng-Shiun Shie, Lisa Rung, Kathleen S. Montine, and Thomas J. Montine Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment. Neurobiol Dis. 2007;25(2):427-437. IF:4.1

5. Ye Xiong, Feng-Shiun Shie, Jing Zhang, Chuan Pu Lee, and Ye-Shih Ho. Prevention of mitochondrial dysfunction in post-trauma mouse brain by superoxide dismutase. J Neurochem. 2005;95(3):732-744. IF: 4.3

6. Feng-Shiun Shie, Kathleen S. Montine, and Thomas J. Montine. Microglial functions in LPS-induced neuronal cytotoxicity: the role of microglial prostaglandin E2 receptors in oxidative stress. Glia. 2005;52(1):70-77. IF: 5.0

7. Feng-Shiun Shie, Kathleen S. Montine, Richard M. Breyer, and Thomas J. Montine. Microglial EP2 as a new target to increase A-beta phagocytosis and decrease A-beta-induced damage to neurons. Brain Pathol. 2005; 15 (2): 134-138. IF: 5.3

8. Feng-Shiun Shie (corresponding author), Richard M. Breyer, Thomas J. Montine. Microglia lacking EP2 have enhanced A-beta phagocytosis yet lack A-beta activated neurotoxicity. Am J Pathol. 2005;166(4):1163-1172. IF: 5.9

9. Jinghua Jin, Gloria E. Meredith, Leo Chen, Young Zhou, Jin Xu, Feng-Shiun Shie, Paul Lockhart, and Jing Zhang. Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson’s disease. Brain Res Mol Brain Res. 2004; 24;134(1):119-138.

10. Dejan Milatovic, Snjezana Zaja-Milatovic, Kathleen S. Montine, Feng-Shiun Shie, and Thomas J. Montine. Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo. J Neuroinflammation. 2004; 21; 1(1): 20. IF: 4.4

11. Yong Zhou, Feng-Shiun Shie, Pedro Piccardo, Thomas J. Montine, Jing Zhang. Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson's disease. Neuroscience. 2004; 128:281-291. IF: 3.4

12. Ye Xiong, Feng-Shiun Shie, Jing Zhang, Chuan-Pu Lee, Ye-Shih Ho. The protective role of cellular glutathione peroxidase against trauma-induced mitochondrial dysfunction in mouse brain. J Stroke Cerebr Dis. 2004; 13:129-137.

13. Feng-Shiun Shie, M. Diana Neely, Izumi Maezawa, Hope Wu, Sandy J. Olson, Günther Jürgens, Kathleen S. Montine and Thomas J. Montine. Oxidized Low-Density Lipoprotein Is Present in Astrocytes Surrounding Cerebral Infarcts and Stimulates Astrocyte Interleukin-6 Secretion. Am J Pathol. 2004; 164:1173-1181. IF: 5.9.

14. Lee-Way Jin, Feng-Shiun Shie (co-first author), Izumi Maezawa, Inez Vincent and Thomas Bird. Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am J Pathol. 2004; 164:975-985 (2004; 165:1447). IF: 5.9

15. Feng-Shiun Shie, Renee C. LeBoeuf, Lee-Way Jin. Early Intraneuronal beta-amyloid deposition in the hippocampus of APP transgenic mice. NeuroReport. 2003; 14:123-129. IF: 2.3

16. Jochen Brich, Feng-Shiun Shie, Brian W. Howell Renhua Li, Katalin Tus, Edward K. Wakeland, Lee-Way Jin, Marc Mumby, Gary Churchill, Joachim Herz, Jonathan A. Cooper. Genetic modulation of tau phosphorylation in the mouse. J Neurosci. 2003; 23:187-192. IF: 7.5


1. Title: Methods and Compositions for Treatment of Neurological Diseases and Disorders. US-2007-0232556-A1.
2. Title: Novel neuro-protective compounds for neurodegenerative diseases. (filing)