Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Ling-Mei Wang, Ph.D.

Associate Investigator
Institute of Molecular and Genomic Medicine
lingmeiwang@nhri.org.tw

EDUCATION

Ph.D., Department of Cellular & Structural Biology, University of Texas Health Science Center at San Antonio, USA (1991)
M.S., Institute of Biology, Tunghai University, Taiwan (1982)
B.S., Department of Biology, Tunghai University, Taiwan (1980)

PROFESSIONAL EXPERIENCES

- Associate Investigator, Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
- Director, Division of Research and Development, Vita Genomics Inc., Taipei, Taiwan
- Senior Research Scientist, Van Andel Research Institute, Grand Rapids, Michigan, USA
- Staff Scientist, National Cancer Institute, NIH, Bethesda, Maryland, USA
- Visiting Associate, National Cancer Institute, NIH, Bethesda, Maryland, USA
- Visiting Fellow, National Cancer Institute, NIH, Bethesda, Maryland, USA

RESEARCH INTERESTS

Dr. Wang research interests are in better understanding the molecular basis of cancer and the regulation of growth and differentiation of stem cells. The research conducted in her laboratory uses a broad range of approaches to elucidate the molecular mechanisms leading to cancer, and to develop tools for the diagnosis, prognosis, and therapy of cancer. Recently, Dr. Wang has also engaged in research and development of stem cell related technology for research and for clinical applications.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Wang has extensive track record on signaling mechanisms involving receptor tyrosine kinases including insulin receptor and EGF receptor (EGFR) family. She has played a pivotal role in the identification and cloning of insulin receptor substrate 2, a signaling molecule that is critical in IL-4, insulin, and IGF-1 receptor signaling. Her recent research has focused on the role of HSF/SF-MET in tumor growth, invasion and metastasis. Most recently, she has demonstrated that the cross-talk between Met and EGFR is essential in some of the biological effects elicited by HGF/SF. Believing in stem cell as future generation of medicine, Dr. Wang has also initiated studies in this research field. It includes the regulation growth and differentiation of stem cell and the development of stem cell technology for clinical applications.

Dr. Wang has authored and co-authored over 70 original research articles. Her professional services include but not limit to, reviewer for research grant proposals and journal articles, lectures and seminars in universities, and committee members for the graduate programs.

SELECTED PUBLICATIONS

1. Wu, L.S.-H., Tan, C.Y., Wang, L.-M., Lin, C.G.-J., and Wang, J.-Y. Variant in promoter region of platelet-derived growth factor receptor-alpha (PDGFRa) gene is associated with the severity and allergic status of childhood asthma. Int Arch Allergy Immunol. 141:37-46, 2006

2. Wang, J.-Y., Wang, L.-M., Lin, C.G.-J., Chang, A.C.-W., and Wu, L.S.-H. Association study using combination analysis of SNP and STRP markers: CD14 promoter polymorphism and IgE level in Taiwanese asthma children. J. Hum. Genet. 50: 36-41, 2005.

3. Zhang, Y.-W., Su, Y., Lanning N, Gustafson M, Shinomiya N, Zhao, P., Cao, B., Tsarfaty G, Wang, L.-M., Hay, R.V., and Vande Woude, G.F. Enhanced growth of human met-expressing xenografts in a new strain of immunocompromised mice transgenic for human hepatocyte growth factor/scatter factor. Oncogene 24: 101-106, 2005.

4. Graveel, C., Su, Y., Koemen, J., Wang, L.-M., Tessarollo, L., Fiscella, M., Birchmeier, C., Swiatek, P., Bronson, R., and Vande Woude, G.F. Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. Proc. Natl. Acad. Sci. U.S.A. 101: 17198-17203, 2004.

5. Lu, C.-H., Lin, C.G.-J., Huang, L., Wang, L.-M., and Wu, L.S.-H. Heterozygosities and allelic frequencies of 811 dinucleotide-repeat marker loci in the Taiwanese population. J. Hum. Genet. 49: 325-333, 2004.

6. Lee, C.-C., Putnam, A.J., Miranti,C.K., Gustafson, M., Wang, L.-M., Vande Woude, G.F., and Gao, C.F. Overexpression of Sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis. Oncogene 23: 51935202, 2004.