Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Kuen-Yuh Wu, Ph.D.

Associate Investigator
Division of Environmental Health and Occupational Medicine
kywu@nhri.org.tw

EDUCATION

Ph.D., Molecular Toxicology, University of North Carolina at Chapel Hill
M.S., Industrial Hygiene and Air Pollution, University of North Carolina at Chapel Hill
M.S., Biomedical Engineering, National Yang-Ming University
B.S., Chemical Engineering, National Tsin-Hua University

PROFESSIONAL EXPERIENCES


- Associate Investigator, Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taiwan (2006 - present)
- Assistant Investigator, Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taiwan (2001-2006)
- Assistant Professor, Department of Occupational Safety and Health, China Medical College, Taichung, Taiwan (1997-2001)

RESEARCH INTERESTS

Dr. Wu's research interests include to develop the state-of-art mass spectrometer techniques to quantitate DNA and protein adducts in humans exposed to carcinogens to serve as risk-associated biomarkers and as an end point for the study of gene-environment interactions and to develop scientific-sound tools and methods for environmental health risk assessment to early detect and predict health risk caused by carcinogen exposures in workplaces and environments. Therefore, workers and the public can be better protected from exposures to chemical hazards.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Wu is one of the eight 2006 Taiwan citation laureate awardees from Thomson Scientific. He helps to establish the Taiwan Society for Risk Analysis and The Taiwan Chapter of Society for Risk Analysis and serves as the secretary general for both organizations. He is a reviewer for 7 top-ranked Environmental Sciences and Analytical Chemistry journals. He has successfully developed mass spectrometry methods to analyze DNA and protein adducts in human blood and urine samples, and was responsible for the establishment of risk assessment system to derive Recommended Exposure Levels in workplaces for Institute of Occupational Safety and Health of Council of Labor Affairs.

SELECTED PUBLICATIONS

1. Huang JCC, Shih WC, Wu CF, Chen MF, Chen YL, Lin TH and Wu KY*. An on-line liquid chromatographic tandem mass spectrometric determination of an ethylene oxide DNA adduct, N7-(2-hydroxyethyl)-guanine, in urine of hospital workers. Accepted by Rapid Communication in Mass Spectrometry.

2. Shih WC, Uang SN, Chen MF, Wu KY*. Simultaneous analysis of 4,4'-methylene-Bi-(2-Chloroaniline) (MOCA) and N-Acetyl-4,4'-methylene-Bi-(2-Chloroaniline) (Acetyl-MOCA) in urine using liquid chromatography coupled with tandem mass spectrometry. Rapid Communication in Mass Spectrometry, 21: 40734078, 2007.

3. Huang JCC, Li CM, Wu CF, Jao SP, Wu KY*. Analysis of urinary N-acetyl-S-(propionamide)-cysteine as a biomarker for the assessment of acrylamide exposure in smokers. Environmental Research, 104:346351, 2007.

4. Shih TS, Wu KY, Chen HI, Chang CP, Chang HY, Huang YS, Liou SH. The development and regulation of occupational exposure limits in Taiwan. Regulatory Toxicology and Pharmacology.46:142-148, 2006.

5. Chiang SY, Huang TH, Uang SN, Wu IHD, Wei YC, Lin HY, Swenberg AJ, Wu KY*. Analysis of 7-methylguanine using Isotope Dilution and Gas Chromatography/Electron Capture-Negative Chemical Ionization Mass Spectrometry. Rapid Communication in Mass Spectrometry. 19:1915-1920, 2005.

6. Li CS*, Wu KY, Chang-Chien CP and ChouCC. Analysis of Oxidative DNA Damage 8-Hydroxy-2¢-deoxyguanosine as a Biomarker of Exposures to Persistent Pollutants for Marine Mammals. Environmental Sciences and Technoogy, 39:2455-2460, 2005.

7. Chen YL, Wang CJ, and Wu KY*. Analysis of N7-(benzo[a]pyrene-6-yl)guanine in urine using two-step solid-phase extraction and isotope dilution with liquid chromatography/tandem mass spectrometry. Rapid Communication in Mass Spectrometry, 19:893-898, 2005.

8. Hu CW, Wu MT, Wu KY*, Wang CJ, Chao MR, Swenberg J and Chang LW. Comparative Analysis of Urinary 8-Hydroxy-2'-Deoxyguanosine by Using Isotope-Dilution Liquid Chromatography Electrospray Tandem Mass Spectrometry and Enzyme-Linked Immunosorbent Assay. Rapid communication in Mass Spectrometry 18:505-510, 2004

(* = Corresponding Author.)

PATENT

l. Solid-Phase Micro-extraction device, Patent No.: 05920048TW