Ming-Shiu Hung, Ph. D.
Institute of Biotechnology and Pharmaceutical Research
EDUCATIONPh.D., Cell and Developmental Biology, Rutgers University, USA (1997)
M.S., Marine Biology, National Sun Yat-Sen University, Taiwan (1987)
B.S., Zoology, National Taiwan University, Taiwan (1985)
PROFESSIONAL EXPERIENCESAssociate Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes (2011- present)
Assistant Investigator, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2004-2011)
Senior Postdoctoral Fellow, Institut Pasteur, Paris, France (2002-2004)
Chercheur Associé, CNRS, France (2003)
Postdoctoral Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan (1997-2002)
RESEARCH INTERESTSObesity has become a widespread epidemic and recognized as one of the top ten global health problems due to its serious comorbidities such as type 2 diabetes and cardiovascular disease. Proper weight control benefits not only in improving the quality of life, but also in reducing the burden of healthcare consumption. We are endeavoring in discovery and development of anti-obesity drugs by antagonizing the function of cannabinoid receptor 1. On the other hand, mechanisms contributing to the occurrence, progression and treatment of metabolic diseases are also the interest of the laboratory.
RESEARCH ACTIVITIES & ACCOMPLISHMENTSThe recent research activity of Dr. Hung focuses on drug discovery by providing biological assay platforms for G protein-coupled receptors and developing animal models for in vivo efficacy and safety studies. Previously, Dr. Hung has been awarded by Association Française des Diabétique for the study on the type 1 diabetes (T1D) susceptibility locus Idd6, and has identified Arntl2 as a candidate gene contributing to T1D disease progression.
HONORS & AWARDSFellowship of Association Française des Diabétique, 2003-2004
Manlio Cantarini (Institut Pasteur) Postdoctoral Fellowship, 2002-2003
NHRI Postdoctoral Fellowship Award, 2000-2002
Academia Sinica Postdoctoral Fellowship Award, 1998-1999
SELECTED PUBLICATIONS1.Tai CL#, Hung MS#, Pawar VD, Tseng SL, Song JS, Hsieh WP, Chiu HH, Wu HC, Hsieh MT, Kuo CW, Hsieh CC, Tsao JP, Chao YS and Shia KS. Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists. Org. Biomol. Chem., 2008. (#equal contribution)
2.Hung MS, Avner P and Rogner UC. Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6. Hum. Mol. Genet., 15: 2732-2742, 2006.
3.Hung MS and Shen CKJ. Eukaryotic methyl-CpG binding domain proteins and chromatin modification. Eukaryotic Cell, 2: 841-846, 2003.
4.Tang LY, Reddy MN, Rasheva V, Lee TL, Lin MJ, Hung MS and Shen CKJ. The eukaryotic DNMT2 genes encode a new class of cytosine-5 DNA methyltransferases. J. Biol. Chem., 278: 33613-33616, 2003.
5.Roder K#, Hung MS#, Lee TL, Lin TY, Xiao H, Isobe KI, Juang JL and Shen CKJ. Transcriptional repression by Drosophila methyl-CpG- binding proteins. Mol. Cell. Biol., 20: 7401-7409, 2000. (#equal contribution)
6.Hung MS, Karthikeyan N, Huang B, Koo HC, Kiger J and Shen CKJ. Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases. Proc. Natl. Acad. Sci USA, 96: 11940-11945, 1999.
7.Wolf F, .Hung MS, Wightman B, Way JC and Garriga G. vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity. Neuron, 20: 655-66, 1998.