Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Chu-Chih Chen, Ph.D.

Associate Investigator
Institute of Population Health Sciences


Ph.D., Biostatistics, University of North Carolina-Chapel Hill, USA (1993)
M.S., Mathematical Statistics, University of North Carolina-Chapel Hill, USA (1988)
B.S., Applied Mathematics, National Tsing-Hua University, Taiwan (1983)


Associate Investigator, Division of Biostatistics and Bioinformatics, National Health Research Institute, (2006-present)
Professor, Department of Mathematics, Tamkang University, Taiwan, (2002 - 2006)
Associate Professor, Department of Mathematics, Tamkang University, Taiwan, (1993 - 2002)


Dr. Chen’s current research interests mainly focus on statistical methodologies and analysis on environmental health statistics and health risk assessment, including toxicokinetic modeling and applications in risk assessment, spatiotemporal statistics, and environmental exposure assessment. He is also interested in (environmental) epidemiology studies based on outcomes of national health surveys and environmental monitoring datasets.


Dr. Chen’s current research activities include: statistical methodologies and applications of PBTK model in exposure assessment; statistical analysis on dioxin exposures; associations between environmental pollutions and residential health status; epidemiology studies on cardiovascular disease. Dr. Chens past publications mainly appear in major statistical journals. He has served as a referee for several (medical) statistics journals.


1. Chen, C.-C. (2008) Extended rank analysis of covariance adjusting for local correlations. Computational Statistics and Data Analysis, 52(3), 1399-1412.

2. Chen, C.-C., Shih, M.-C., Wu, K.-Y., Sen, P. K. (2007) Exterior exposure estimation using a one-compartment toxicokinetic model with blood sample measurements. Journal of Mathematical Biology (in press). E-publication: Sept 25, 2007.

3. Chen, C. C., Wu, K. Y., & Chang, W. M. J. A statistical assessment on the stochastic relationship between biomarker concentrations and environmental exposures. Stochastic Environmental Research and Risk Assessment. 18:377-385, 2004.

4. Chen, C. C., Wu, K. Y., & Balakrishnan, N. Two-sample scale tests for comparison of metabolic rates for styrene in previously exposed and unexposed groups. Statistics in Medicine. 23:591-599, 2004.

5. Chen, C.-C. Rank estimating equations for random effects models. Statistics and Probability Letters. 54:5-12, 2001.

6. Chen, C.-C. Rank analysis of covariance as a more efficient matched analysis considering trend information. Biometrical Journal. 43(7):895-907, 2001.