Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Kenneth K. Wu, M.D., Ph.D.

Distinguished Investigator and President
Acting Director
Institute of Cellular and Systems Medicine
kkgo@nhri.org.tw

EDUCATION

  • Ph.D., University of London, UK
  • M.S., Yale University School of Medicine, USA
  • M.D., National Taiwan University College of Medicine, Taiwan

    PROFESSIONAL EXPERIENCES

  • Distinguished Chair Professor, National Taiwan University College of Medicine, Taiwan (2007-present)
  • President, National Health Research Institutes, Taiwan (2006-present)
  • Distingnished Investigator and Acting Director, Cardiovascular and blood Research Center, National Health Research Institutes, Taiwan (2006-present)
  • Roy M. and Phyllis Gough Huffington Chair in Gerontology, University of Texas-Houston Health Science Center, USA (1992-2006)
  • Professor and Director, Division of Hematology, University of Texas Health Science Center at Houston, USA (1983- 2006)
  • Vice Chairman, Department of Medicine, University of Texas Medical School at Houston, USA (1990-2006)
  • Director, Vascular Biology Research Center, University of Texas Health Science Center at Houston, USA (1988- 2006)
  • Professor, Department of Blood and Marrow Transplantation, University of Texas M.D. Anderson Cancer Center, USA (2004-2006)
  • Associate Director, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, USA (2002-2006)
  • Founding Director, General Clinical Research Center, University of Texas at Houston, USA (1985-1991)

    RESEARCH INTERESTS

    Dr. Wu has a long term interests in two areas of research: (1) Prostaglandin and nitric oxide synthesis and biological activities and (2) Haemostatic and genetic risk of arterial thrombosis. Ongoing research work includes identification and purification of endogenesis factors that central cyclooxygenase-2 (COX-2) expression in proliferating cells, elucidation of mechanisms by which salicylate inhibits transcriptional activation, and the novel actions of prostaglandins on adult cell and embryonic stem cell survival, differentiation and proliferation.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Wu's laboratory is the first to suggest an inducible form of COX and one of thetwo laboratories to clone prostacyclin (PGI) and the thromboxane (TXA) syntheses. He has pioneered the use of adenoviral mediated cox and PGI synthase gene transfer in preventing cell apoptosis and tissue infarction. He has made major contributions in establishing platelet and haemostatic factors as risk factors of arterial thrombosis and the pharmacological mechanisms of aspirin. He has given lectures in important international symposia and served as associate editor and on several editorial boards of major scientific and medical journals.

    HONORS & AWARDS

  • SANOFI Prize, SANOFI Association for Thrombosis Research and International Society of Thrombosis and Haemostasis (1997)
  • Member, American Association of Physicians (1997)
  • Academician (Member), Academia Sinica, Taiwan (1994)
  • Member, American Society of Clinical Investigation (1982)
  • Member, European Academy of Science

    SELECTED PUBLICATIONS

    1.Liou JY, Ghelani D, Yeh S, Wu KK. Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon. Cancer Res. 67:3185-3191, 2007.

    2.Deng, W.G., Tang, S.T., Tseng, H.P., Wu, K.K. Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding. Blood. 108: 518-24, 2006.

    3.Liou, J.Y., Lee, S., Ghelani, D., Matijevic-Aleksic, N., Wu, K.K. Protection of endothelial survival by peroxisome proliferator-activated receptor-{delta} mediated 14-3-3 upregulation. Arterioscler. Thromb. Vasc. Biol. 26: 1481-7, 2006.

    4.Wu, K.K., Liou, J.Y. Cellular and molecular biology of prostacyclin synthase. Biochem Biophys Res Commun. 338: 45-52, 2005. (Invited Review for the 50th Anniversary of Discovery of Oxygenases)

    5.Cieslik, K., Zhu, Y., Shtivelband, M., Wu, K.K. Inhibition of p90 ribosomal S6 kinase-mediated C/EBPbeta activation and COX-2 expression by salicylate. J. Biol. Chem. 280: 18411-18417, 2005.

    6.Wu, K.K., Aleksic, N., Ballantyne, C.M., Ahn, C., Juneja, H., Boerwinkle, E. Interaction between soluble thrombomodulin and intercellular adhesion molecule-1 in predicting risk of coronary heart disease. Circulation. 107:1729-1732, 2003.

    7.Deng, W., Saunders, M.A., Gilroy, D.W., He, X-Z., Yeh, H., Zhu, Y., Shtivelband, M.I., Ruan, K-H., Wu, K.K. Purification and characterization of a cyclooxygenase-2 and angiogenesis suppressing factor produced by human fibroblasts. FASEB J. 16: 1286-1288, 2002.

    8.Xu, X-M., Sansores-Garcia, L., Chen, X-M., Matijevic-Aleksic, N., Du, M., Wu, K.K. Suppression of inducible cyclooxygenase-2 gene transcription by aspirin and sodium salicylate. Proc Natl Acad Sci U S A. 96:5292-5297, 1999.