Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Ching-Liang Chu, Ph.D.

Assistant Investigator
Immunology Research Center
clchu@nhri.org.tw

EDUCATION

-Ph.D., Life Science, National Defense Medical Center/Academia Sinica, Taiwan(2000)
-M.S., Radiation Biology, National Tsing Hua University, Taiwan(1991)
-B.S., Plant Pathology, National Chung Hsin University, Taiwan(1989)

PROFESSIONAL EXPERIENCES

  • Assistant Investigator, Immunology Research Center, National Health Research Institutes (2008-present)
  • Assistant Investigator, Vaccine Research and Development Center, National Health Research Institutes (2005-2007)
  • Postgraduate Researcher, Dept. of Laboratory Medicine, UCSF, San Francisco, CA, USA (2002-2005)
  • Postdoctoral Fellow, Pulmonary Div., Dept. of Medicine, UCSF, San Francisco, CA, USA (2000-2002)

    RESEARCH INTERESTS

    Dr. Chu's major interest is to establish the dendritic cell (DC)-based platform technology. His current research is to study the role of tyrosine kinases and adapters in DC biology and screen immunomodulator for the application in vaccination and immunotherapy. The goal is to understand DC biology and apply the knowledge to discover new agent for immunomodulation.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Chu has authored 8 original research articles and 15 meeting abstracts.

    HONORS & AWARDS

  • Dr. Chien-Tien Hsus award for Ph.D. thesis, The Chinese Society of Cell and Molecular Biology, Taiwan, 2000

    SELECTED PUBLICATIONS

    1. Chu, C.-L., and Lowell, C.A. The Lyn Tyrosine Kinase Differentially Regulates Dendritic Cell Generation and Maturation. J. Immunol. 175, 2880-2889, 2005.
    2. Zhang, H., Meng, F., Chu, C.-L., Takai T., and Lowell, C.A. The Src-family kinases Hck and Fgr negatively regulate chemokine signaling in neutrophils and dendritic cells through inhibitory receptor PIR-B. Immunity 22, 235-246, 2005.
    3. Wu, Z.-Q., Shen, Y., Khan, A.Q., Chu, C.-L., Riese, R., Chapman, H.A., Kanagawa, O., and Snapper, C.M. The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus pneumoniae is dependent on the type of antigen. J. Immunol. 168, 5551-5557, 2002.
    4. Riese, R.J., Shi, G.-P., Villadangos, J., Stetson, D., Driessen, C., Lennon-Dumenil, A.-M., Chu, C.-L., Naumov, Y., Behar, S.M., Ploegh, H., Locksley, R., and Chapman, H.A. Regulation of CD1 function and NK1.1+ T cell selection and maturation by cathepsin S. Immunity 15, 909-919, 2001.
    5. Chu, C.L., Hsiao, Y.Y., Chen, C.H., Van, R.C., Lin, W.J., and Pan, R.L. Inhibition of plant vacuolar H+-ATPase by diethylpyrocarbonate. Biochim. Biophys. Acta 1506 (Bioenergetics), 12-22, 2001.