Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Shu-Ching Hsu, Ph.D.

Assistant Investigator
Vaccine Research and Development Center
mschsu@nhri.org.tw

EDUCATION

  • Ph.D., Microbiology, National Taiwan University, Taiwan, 2000
  • M.S., Microbiology and Immunology, National Yang-Ming University, Taiwan, 1995
  • B.S., Microbiology, Soochow University, Taiwan, 1993

    PROFESSIONAL EXPERIENCES

  • Member, Taiwan Society for Stem Cell Research (TSSCR) (2006-present)
  • Assistant Investigator, Vaccine Research and Development Center, National Health Research Institutes, Taiwan (2005-present)
  • Postdoctoral Research Fellow, Center for Gene Therapy, Tulane University, Louisiana, USA (2002-2005)
  • Trainer of the annual short course in medical and experimental mammalian genetics in The Jackson Laboratory, USA (2005)
  • Postdoctoral Research Fellow, Institute of Molecule Biology, Academia Sinica, Taiwan (2000-2002 )
  • Member, the International Society for Stem Cell Research (2003-present)

    RESEARCH INTERESTS

    Dr. Hsu's research interests include identification and characterization of immunomodulation activity in mesenchymal stem cells (MSCs), regulation of immune tolerance and transplantation for cellular therapy, and the establishment of animal models for studying of human infectious diseases and vaccination. Current research project of Dr. Hsu is focus on how MSCs alter the outcome of differentiation and effecter function in different kind of immune cells and whats the application of the ability of immuno-modulation derived form MSCs in vaccination and immunotherapy.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Hsu has authored 12 original research articles and 4 abstracts for international scientific research meetings. She also has been an invited speaker in 2 international symposia on the stem cells field. Dr. Hsu has established the MKK3/6 DN transgenic system for studying the roles of p38 signaling pathway during the development and activation of T lymphocytes. She was recognized by research contribution of knowing the regulation of Fas and FasL within T cell activation. Recently, characterization of MSCs of her work was indicated the importance of cell status and specific expression molecules on stem cells could determine the out come of tissue distribution after cellular transplantation. The roles of genetic and epigenetic controlling machinery of MSC in developmental biology and immunology will be the focus of future investigation. Furthermore, Dr. Hsu will continue to make efforts in establishment of humanized mice model system and provides the various screening platforms both in vitro and in vivo to support vaccine projects within VRDC.

    HONORS & AWARDS

  • Scholarship winner of Postdoctoral training of Ministry of Education, Taiwan, 2001 (Supported Grant: 2002-2004)
  • Award of excellent Ph.D. thesis sponsored by Dr. Chien-Tien Hsu, 2000
  • Award of excellent Ph.D. student sponsored by Dr. Fong-Wen Shen, 1998, 1999
  • Award of excellent master thesis sponsored in IMB, Academia Sinica, 1995
  • Winner of scholarship of The Phi Tau Phi Scholastic Honor Society, 1993

    SELECTED PUBLICATIONS

    1.Hung SC, Pochampally RR, Chen SC, Hsu SC, Prockop DJ. Angiogenic Effects of Human Multipotent Stromal Cell Conditioned Medium Activates the PI3K-Akt Pathway in Hypoxic Endothelial Cells to Inhibit Apoptosis, Increase Survival, and Stimulate Angiogenesis. Stem Cells. 25(9): 2363-70, 2007.

    2.Hung SC, Pochampally RR, Hsu SC, Sanchez C, Chen SC, Spees JL, Prockop DJ. Short-Term Exposure of Multipotent Stromal Cells to Low Oxygen Increases Their Expression of CX3CR1 and CXCR4 and Their Engraftment In Vivo. PLoS ONE. 2: e416, 2007.

    3.Lee RH, Hsu SC, Munoz J, Jung JS, Lee NR, Pochampally R, Prockop DJ. A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice. Blood. 107(5):2153-61, 2006.

    4.Smith JR, Pochampally R, Perry A, Hsu SC, Prockop DJ. Isolation of a highly clonogenic and multipotential subfraction of adult stem cells from bone marrow stroma. Stem Cells. 22(5):823-31, 2004.

    5.Spees JL, Gregory CA, Singh H, Tucker HA, Peister A, Lynch PJ, Hsu SC, Smith J, Prockop DJ. Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy. Mol Ther. 9(5):747-56, 2004.

    6.Wu CC, Hsu SC, Shih HM, Lai MZ. Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cells. Mol Cell Biol. 23(18):6442-54, 2003.

    7.Hsu SC, Wu CC, Han J, Lai MZ. Involvement of p38 mitogen activated protein kinase in different stages of thymocyte development. Blood. 101(3):970-6, 2003.