Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Pinpin Lin, Ph.D.

Investigator
Division of Environmental Health and Occupational Medicine
pplin@nhri.org.tw

EDUCATION

Ph.D., Toxicology, The University of Michigan, Ann, Arbor, USA, 1994.
M.S., Biochemistry, National Taiwan University, Taipei, Taiwan, 1987.
B.S., Pharmacy, Taipei Medical College, Taipei, Taiwan, 1985.

PROFESSIONAL EXPERIENCES

- Adjunct Professor, Institute of Medical and Molecular Toxicology, Chung-Shan Medical University, Taichung, Taiwan (2006-present)
- Adjunct Associate investigator, Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taiwan (2004-2006)
- Professor, Institute of Medical and Molecular Toxicology, Chung-Shan Medical University, Taichung, Taiwan (2004-2006)
- Professor, Institute of Toxicology, Chung-Shan Medical University, Taichung, Taiwan (2003-2004)
- Associate professor, Institute of Toxicology, Chung-Shan Medical and Dental College, Taichung, Taiwan (1996- 2003)

RESEARCH INTERESTS

Dr. Lin's research interest is the environmental risk factors for lung cancer. Her laboratory has been trying to elucidate the relationship between aryl hydrocarbon receptor (AhR) signaling pathway and lung cancer. Carcinogenic AhR agonists include polycyclic and halogenated aromatic hydrocarbons Research efforts by Dr. Lin and her collaborators at NHRI also unveiled important scientific information on roles of certain environmental factors (cooking oil fume, dioxins, motorcycle exhausts, etc.) in relationship to female lung cancer development. In addition, Dr. Lin's research team at NHRI, in collaboration with scientists at NCKU, further conducted animal studies to explore interactions between cigarette smoke and environmental factors, such as dioxins and arsenic, in the enhancements of lung cancer development which is becoming an alarming health concern in Taiwan.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Lin actively participates in the annual meeting of American Society of Toxicology as well as The Toxicology Society of Taiwan. She was invited as a speaker in the annual meeting of The Toxicology Society of Taiwan. Dr. Lin has served on review for some international scientific journals and governmental grants review in Taiwan. Dr. Lin has been participating in National Genomic Research Programs for Female Lung Cancer since 2000. Dr. Lin has established a relationship between AhR, cytochrome P4501B1 expression and the early development of lung adenocarcinoma in Taiwan as well as relationship between cytochrome P4501B1 expression and exposure to AhR agonists in human. In addition, she has established several experimental models, including in vitro human lung cell cultures, in vitro lung tissue slice cultures and in vivo intratracheal exposure model. Recently, Dr. Lin participates in National Science and Technology Program for Nanoscience and Nanotechnology to evaluate safety of nanomaterials in vivo.

SELECTED PUBLICATIONS

1. Chang YC and Lin P*. Trans, trans-2, 4-decadienal induced cell proliferation via p27 pathway in human bronchial epithelial cells. Toxicol. Appl. Pharmacol. 2008 (In press)

2. Lee HL, Chang LW, Wu JP, Ueng YF, Tsai MH, Hsieh DPH and Lin P *. Enhancement of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism and carcinogenic risk via NNK/Arsenic interaction. Toxicol. Appl. Pharmacol. 2008 (In press)

3. Yang RSH, Chang LW, Wu JP, Tsai MH, Wang HJ, Kuo YC, Yeh TK, Yang CS and Lin P*. Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment. Environmental Health Perspectives 115: 1339-1343, 2007.

4. Chang LW, Chang YC, Ho CC, Tsai MH, and Lin P*. Increase of carcinogenic risk via enhancement of cyclooxygenase-2 expression and hydroxyestradiol accumulation in human lung cells as a result of interaction between BaP and 17-beta estradiol. Carcinogenesis 28: 1606-1612, 2007.

5. Cheng YH, Chang LW, Cheng LC, Tsai MH and Lin P*. 4-Methoxyestradiol induced oxidative injuries in human lung epithelial cells Toxicol. Appl. Pharmacol. 220: 271-277, 2007.

6. Chang JT, Chang H, Chen PH, Lin SL, and Lin P*. Requirement of AhR overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas. Clin. Cancer Res. 13: 38-45, 2007.

7. Chang H, Chang LW, Cheng YH, Tsai WT, Tsai MX and Lin P*. Preferential induction of CYP1A1 and CYP1B1 in CCSP-positive cells. Toxicol. Sciences 89(1): 205-213, 2006.

8. Chang LW, Lo WS and Lin P*. Trans, trans-2,4-decadienal, a product found in cooking oil fumes, induces cell proliferation and cytokine production due to reactive oxygen species in human bronchial epithelial cells. Toxicol. Sciences 87(2): 337-343, 2005.

9. Lin P, Wang SL, Wang HJ, Chen KW, Lee HS, Tsai KJ, Chen CY and Lee H. Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma. British J. Cancer 82(4):852-857, 2000.