Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Yao Chang, Ph.D.

Assistant Investigator
Division of Infectious Diseases


  • Ph.D., Graduate Institute of Microbiology, National Taiwan University, Taiwan, 2000
  • B.S., Department of Zoology, National Taiwan University, Taiwan, 1994


  • Assistant Investigator, Division of Clinical Research, National Health Research Institutes, Taiwan (2005-present)
  • Postdoctoral Fellow, Graduate Institute of Microbiology, National Taiwan University (2000-2004)
  • Postdoctoral Fellowship Award, National Health Research Institutes, Taiwan (2001-2002)
  • Member, International Association for Research on Epstein-Barr Virus and Associated Diseases (2000-present)


    Dr. Chang’s research interests are focused on Epstein-Barr virus (EBV) and its associated human cancers. His research team is approaching pathogenic roles of EBV in the cancer development through studying the virus-host interaction. His ongoing projects include regulation of EBV oncogenes in malignant cells, EBV reactivation-induced inflammatory events, and immunosuppressive effects in the microenvironments of EBV-associated tumors.


    In the starting stage of his research carrier, Dr. Chang has achieved several original studies in the EBV field, including the mechanism of EBV infection of epithelial cells, regulation of viral and cellular genes in EBV-associated tumor cells, and modulation of EBV reactivation.


  • Postdoctoral Fellowship Award, National Health Research Institutes, Taiwan, 2001
  • Outstanding Publication Award for Graduate Students of College of Medicine, National Taiwan University, Taiwan, 2001
  • Honorary Member of the Phi Tau Phi Scholastic Honor Society at National Taiwan University, Taiwan, 2000
  • Professor Chih-Chung Yen’s Scholarship Award of Chinese Society of Microbiology, Taiwan, 1995


    1.Hsieh WC, Chang Y, Hsu MC, Hsiao GC, Chuang HC and Su IJ. Emergence of anti-red blood cell antibodies triggers red cell phagocytosis by activated macrophages in a rabbit model of Epstein-Barr virus-associated hemophagocytic syndrome. American Journal of Pathology, 170:1629-1639, 2007.
    2.Chang Y, Lee HH, Chen YT, Lu J, Wu SY, Chen CW, Takada K and Tsai CH. Induction of the early growth response-1 gene by Epstein-Barr virus lytic transactivator Zta. Journal of Virology, 80:7748-7755, 2006.
    3.Chang Y, Lee TC, Li JC, Lai TL, Chua HH, Chen CL, Doong SL, Chou CK, Sheen TS and Tsai CH. Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma. Head & Neck, 27:873-882, 2005.
    4.Chang Y, Lee HH, Chang SS, Hsu TY, Wang PW, Chang YS, Takada K and Tsai CH. Induction of Epstein-Barr virus latent membrane protein 1 by a lytic transactivator Rta. Journal of Virology, 78:13028-13036, 2004.
    5.Chang Y, Chang SS, Lee HH, Doong SL, Takada K and Tsai CH. Inhibition of the Epstein-Barr virus lytic cycle by Zta-targeted RNA interference. Journal of General Virology, 85:1371-1379, 2004.
    6.Chang Y, Cheng SD and Tsai CH. Chromosomal integration of Epstein-Barr virus genomes in nasopharyngeal carcinoma cells. Head & Neck, 24:143-150, 2002.
    7.Chang Y, Tung CH, Huang YT, Lu J, Chen JY and Tsai CH. Requirement for cell-to-cell contact in Epstein-Barr virus infection of nasopharyngeal carcinoma cells and keratinocytes. Journal of Virology, 73:8857-8866, 1999.