Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Feng-Jui Chen, Ph.D.

Assistant Investigator
Division of Infectious Diseases
frchen@nhri.org.tw

EDUCATION

Ph.D., Aquaculture, National Taiwan Ocean University, Taiwan, 1999
M.S., Marine Biology, National Taiwan Ocean University, Taiwan, 1993
B.S., Aquaculture, National Taiwan Ocean University, Taiwan, 1991

PROFESSIONAL EXPERIENCES

  • Assistant Investigator, Division of Clinical Research, National Health Research Institutes, Taiwan (2006-present)
  • Research Associate, Division of Clinical Research, National Health Research Institutes, Taiwan (2004-2006)
  • Research Associate, Institute of Infection, Immunity and Inflammation, University of Nottingham, UK (2003-2004)
  • Postdoctoral Fellow, Division of Clinical Research, National Health Research Institutes, Taiwan (1999-2003)

    RESEARCH INTERESTS

    Dr. Chens main research interests include virulence regulation and drug resistance in Staphylococcus aureus. Current focus is on the regulation of virulence genes by a quorum sensing system. Quorum sensing is one particular form of cell-to-cell communication, in which genes are expressed in response to changes in population density. The opportunity is there for the exploitation of quorum sensing as a novel target for anti-infective therapy. It will be interesting to see this opportunity translated into clinical reality.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Chen had studied the molecular mechanisms of fluoroquinolone reduced susceptibility in Escherichia coli and Klebsiella pneumoniae and has published some research articles about this issue.

    SELECTED PUBLICATIONS

    1.Chen FJ, Lauderdale TL, Huang IW, Lo HJ, Lai JF, Wang HY, Shiau YR, Chen PC, Ito T and Hiramatsu K. Methicillin-Resistant Staphylococcus aureus in Taiwan. Emerg Infect Dis., 11:1761-1763, 2005.
    2.Chen FJ, Lauderdale TL, McDonald LC, Chen PC, Yin HC, Ho M and Lo HJ. Molecular Epidemiology of the Emerging Fluoroquinolone Reduced Susceptible Escherichia coli. J Med. Microbiol., 53:85-86, 2004.
    3.Chen FJ, Lauderdale TL, Ho M, and Lo HJ. The Roles of Mutations in gyrA, parC, and ompK35 in Fluoroquinolone Resistance in Klebsiella pneumoniae. Microb. Drug Resist., 9:265-271, 2003.
    4.Chen FJ, McDonald LC, Ho M and Lo HJ. Identification of Reduced Fluoroquinolone Susceptibility in Escherichia coli: A Herald for Emerging Resistance. J Antimicrob. Chemother., 48:936-938, 2001.
    5.McDonald LC, Chen FJ, Lo HJ, Yin HC, Lu PL, Huang CH, Chen PC, Lauderdale TL and Ho M. Emergence of Reduced Susceptibility and Resistance to Fluoroquinolones in Escherichia coli in Taiwan and Contributions of Distinct Selective Pressures. Antimicrob. Agents Chemother., 45:3084-3091, 2001.