Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Chun-Keung Yu, Ph.D.

Joint-appointed Investigator
Division of Infectious Diseases
dckyu@mail.ncku.edu.tw

EDUCATION

Ph.D., Experimental Pathology, Department of Comparative Medicine, University of Alabama, USA
B.V.M., Veterinary Medicine, National Taiwan University, Taiwan

PROFESSIONAL EXPERIENCES

- Joint-appointed Investigator, Division of Clinical Research, National Health Research Institutes, Taiwan (2005-present)
- Associate director, Head, National Laboratory Animal Center, National Applied Research Laboratories, R/D (2005-present)
- Professor, National Cheng Kung University, Taiwan (2004-present)
- Director, Laboratory Animal Center, National Cheng Kung University (2002 -present)
- Associate professor, National Cheng Kung University (1996-2004)
- Lecturer, National Cheng Kung University (1994- 1996)
- Teaching Assistant, National Cheng Kung University (1986 -1994)

RESEARCH INTERESTS

Dr. Yu's early research involved the pathogenesis of allergic asthma. In 1998, he commenced his work on EV71. His current interests are EV71 pathogenesis, photodynamic inactivation of microorganisms, and epidemiology of murine pathogens in animal facilities of Taiwan.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Yu's team have provided EV71 monoclonal antibodies to ScinoPham Biotech for developing humanized EV71 Ab (patent pending), and collorated with Taiwan Livestock Research Institute for explorating the feasibility of using IgY for the prevntion of EV71 infection.

Since 2002, Dr. Yu has developed, nurtured, and managed the animal program of National Cheng Kung University, which provides college-wide laboratory animal resources for faculties and students. As the associate director of the National Laboratory Animal Center (NLAC), he has been actively involved in the design, coordination, and supervision of the construction of the second division in Southern Science Park, Tainan, and helped NLAC to evolve into a research institute. He initiated a study using germfree mice to screen potential probiotics with immunomodulatory activities at NLAC in 2006 (with a 3-year grant support from NSC).

SELECTED PUBLICATIONS

1. Wang SM, HY Lei, MC Huang, LY Su, HC Lin, CK Yu, JL Wang, CC Liu. Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis. Journal of Clinical Virology. 37:47-52, 2006.
2. Liu ML, YP Lee, YF Wang, HY Lei, CC Liu, SM Wang, IJ Su, JR Wang, TM Yeh, SH Chen, CK Yu*. Type I interferons protect mice against enterovirus 71 infection. The Journal of General Virology. 86:3263-3269, 2005.
3. Wang YF, CT Chou, HY Lei, CC Liu, SM Wang, JJ Yan, IJ Su, JR Wang, TM Yeh SH Chen and CK Yu*. A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection. The Journal of Virology. 78:7916-7924, 2004.
4. Chen YC, CK Yu, YF Wang, CC Liu, IJ Su HY Lei. A murine oral model enterovirus 71 infection model with central nervous system involvement. The Journal of General Virology. 85:69-77, 2004.
5. Yu CK*, CL Chen. Activation of mast cells is essential for development of house dust mite Dermatophagoides farinae-induced allergic airway inflammation in mice. The Journal of Immunology. 171:3808-3815, 2003.
6. Chen CC, CT Lee, YC Liu, JY Wang, HY Lei, CK Yu*. House dust mite Dermatophagoides farinae augments proinflammatory mediator productions and accessory function of alveolar macrophages: implications for allergic sensitization and inflammation. The Journal of Immunology. 2003; 170:528-536.
7. Yu CK*, CC Chen, CL Chen, JR Wang, CC Liu, JJ Yan, IJ Su. Neutralizing antibody provided protection against enterovirus type 71 lethal challenge in neonatal mice. Journal of Biomedical Science. 7:523-528, 2000.