Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Jiunn-Jong Wu, Ph.D.

Joint-appointed Investigator
Division of Infectious Diseases
jjwu@mail.ncku.edu.tw

EDUCATION

-Ph.D., Department of Microbiology & Immunology, Temple University, USA
-M.S., Department of Microbiology, Thomas Jefferson University, USA
-B.S., Department of Medical Technology, Thomas Jefferson University, USA

PROFESSIONAL EXPERIENCES

- Joint-appointed Investigator, Division of Clinical Research, National Health Research Institutes, Taiwan
- Director, Institute of Molecular Medicine, College of Medicine, National Cheng-Kung University, Taiwan
- Chairman, Department of Medical Technology, College of Medicine, National Cheng-Kung University, Taiwan
- Professor, Department of Medical Technology and Institute of Molecular Medicine, College of Medicine, National Cheng-Kung University, Taiwan
- Associate Professor, Department of Medical Technology, College of Medicine, National Cheng-Kung University, Taiwan
- Postdoctoral Fellow, Department of Molecular Experimental Medicine, Research Institute of Scripps Clinic, ,La Jolla, CA. USA

RESEARCH INTERESTS

Dr. Wu's research mainly focuses on mechanisms of antimicrobial resistance, hospital infection and bacterial pathogenesis. For antimicrobial resistance, he is interested in macrolide-resistant of Gram positive cocci and beta lactamase of Gram negative bacteria. For bacterial pathogenesis, Group A streptococcus, Escherichia coli and Helicobacter pylori are research interests.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Wu has emphasized on macrolide-resistance in group A streptococcus (GAS) and beta lactamase resistance of gram negative enteric bacteria. In Klebsiella pneumoniae, Dr. Wu's team not only found that SHV-12 is the major ESBL strain in Taiwan but also discovered several novel b-lactamases (CMY-8, IMP-8). In E. coli, they found that CTX-M-3 and CMY-2 b-lactamase for the first time appeared in Asia, and dissemination of CMY-2 b-lactamase came from food animals and retail ground meats. In addition, they also found the interspecies spread and horizontal transfer of CMY-2 b-lactamase between E. coli, K. pneumoniae and Salmonella. For Helicobacter pylori pathogenesis, Dr. Wu's team found that all the H. pylori isolates in Taiwan had a positive babA2 genotype and patients who expressed Leb had a higher H. pylori density than those who did not express Leb. In addition to H. pylori, they have studied GAS for many years. They found that streptococcal erythrogenic toxin B (SpeB) is associated with invasive group A streptococcal disease. They also demonstrated that SpeB is a very important virulence factor.

SELECTED PUBLICATIONS

1. Tseng CC, Huang JJ, Wang MC, Wu AB, Ko WC, and Wu JJ*. PapG II adhesin in the establishment and persistence of Escherichia coli infection in mouse kidneys. Kidney International. 2006 (accepted)
2. Sheu BS, Odenbreit S, Hung KH, Liu CP, Sheu SM, Yang HB, and Wu JJ*. Interaction of host gastric sialyl-Lewis X and H. pylori SabA enhances the H. pylori density in patients lacking the gastric Lewis B antigen. American Journal of Gastroenterology 101:36-44, 2006.
3. Yan JJ, Chiou CS, Lauderdale Yang TL, Tsai SH and Wu JJ*. Resistance to extended-spectrum cephalosporins and ciprofloxacin in Salmonella, Taiwan. Emerging Infectious Diseases 11:947-950, 2005.
4. Wang CH, Lin CY, Luo YH, Tsai PJ, Lin YS, Lin MT, Chuang WJ, Liu CC, and Wu JJ*. Effects of oligopeptide permease with group A streptococcal infections. Infection & Immunity 73:2881-2890, 2005.
5. Sheu BS, Sheu SM, Yang HB, Huang AY, and Wu JJ*. Clinico-histological relevance of host gastric lewis expressions and babA2 genotype of H. pylori infection. Gut 52:927-932, 2003.
6. Yan JJ, Ko WC, Chiu CH, Tsai SH, Wu HM, and Wu JJ*. Emergence of ceftriaxone-resistant Salmonella isolates and rapid spread of plasmid-encoded CMY-2-like cephalosporinase, Taiwan. Emerging Infectious Diseases 9:323-328, 2003.