Yao-Shen Chen, M.D.
Joint-appointed Assistant Investigator
Division of Infectious Diseases
EDUCATIONM.D., Medicine, School of Medicine, National Yang-Ming University, Taiwan
PROFESSIONAL EXPERIENCESSection head, Section of Infectious Diseases, Kaohsiung Veterans General Hospital, Taiwan (2006-present)
Joint-appointed Assistant Investigator, Division of Clinical Research, National Health Research Institutes, Taiwan (2005-present)
Unit head, Infection Control Unit, Kaohsiung Veterans General Hospital, Taiwan (2005-present)
Executive Secretary, Infection Control Committee, Kaohsiung Veterans General Hospital, Taiwan (2002-present)
Research Fellow, Anti-infective Research Center, Department of Pathology, University of Iowa, USA (1997-1998)
Attending physician, Kaohsiung Veterans General Hospital, Taiwan (1993-present)
Chief Resident, Kaohsiung Veterans General Hospital, Taiwan (1991-1993)
Residency, Kaohsiung Veterans General Hospital, Taiwan (1988-1993)
Residency, Long Chung Veterans Hospital, Pingtung, Taiwan (1986-1988)
Internship, Taipei Veterans General Hospital, Taiwan (1984-1986)
RESEARCH INTERESTSDr. Chen has 6 major areas of interest including investigation of the effectiveness and safety of new antimicrobial agents through clinical trials, analysis of the epidemiology and clinical characteristics of special pathogens, investigation of the immunogenesity and epidemiology of Burkholderia pseudomallei, exploration of the environmental factors of community-and hospital-acquired Legionnaires’ disease, control and appropriation of the use of antibiotics in the treatment of infectious diseases, particularly in the field of prophylactic use of antibiotics in surgery and investigation of the epidemiology of hospital-acquired infection and strategies in the improvement of infection control.
RESEARCH ACTIVITIES & ACCOMPLISHMENTSIn 1999, a study dealing with the issue of the magnitude and cost of surgical prophylaxis in a representative general hospital in Taiwan was performed. Misuse and overuse of prophylactic antibiotics in surgery were found which reflects the actual practice in most surgical departments in hospitals in Taiwan. Great accomplishments have been achieved in optimizing the appropriate use of prophylactic antibiotics in surgery through stepwise strategies, which included continuous educational program, conducting a series of comparable clinical trials, and data-feedback from theprospective surveillance.
A series study of melioidosis, including the environmental factors and epidemiology, have been done to illuminate the hyperendemic situation of melioidosis in southern Taiwan and to demonstrate the immunogenesity and anti-Burkholderia pseudomallei activity in mice of plasmid DNA encoding flagellin.
SELECTED PUBLICATIONS1.Chen YS, Hsiao YS, Lin HH, Liu Y and Chen YL. CpG-Modified Plasmid DNA Encoding Flagellin Improves Immunogenicity and Provides Protection against Burkholderia pseudomallei Infection in BALB/c Mice. Infect Immun., 74(3):1699-705, 2006.
2.Chen YS, Hsiao YS, Lin HH, Yen CM, Chen SC and Chen YL. Immunogenicity and anti-Burkholderia pseudomallei activity in Balb/c mice immunized with plasmid DNA encoding flagellin. Vaccine, 24(6):750-8, 2006. [Epub 2005 Sep.]
3.Huang TS, Lee SS, Chen YS, Tu HZ, Huang WK and Liu YC. Discordant molecular characterization results in a Mycobacterium avium complex strain isolated from an AIDS patient. J Med Microbiol., 54(Pt 7):68-3, 2005.
4.Chen YS, Liu YC, Lee SS, Tsai HC, Wann SR, Kao CH, Chang CL, Huang WK, Huang TS, Chao HL, Li CH, Ke CM and Lin YE. Abbreviated duration of superheat-and-flush and disinfection of taps for Legionella disinfection: Lessons learned from failure. Am J Infect Control, 33(10):606-610, 2005.
5.Chen YS, Chen SC, Wu TR, Kao CM and Chen YL. Seroprevalence of Anti-Flagellin Antibody against Burkholderia pseudomallei in Taiwan. Jpn J Infect Dis., 57(5):224-5, 2004.
6.Lee SS, Liu YC, Chen YS, Tsai HC, Wann SR and Kao CH. Insufficient evidence that extended-spectrum cephalosporins effectively prevent metastatic infections related to Klebsiella pneumoniae-caused liver abscess. Antimicrob Agents Chemother., 48(9):3640, 2004.
7.Chen YS, Lee SC and Kim WJ. Efficacy and tolerability of linezolid in treating severe skin and soft tissue infections caused by cram-positive pathogens. J Formos Med Assoc., 103(5):349-54, 2004.