Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Shankung Lin, Ph.D.

Assistant Investigator
Institute of Cellular and Systems Medicine


Ph.D., Toxicology Program, University of Maryland at Baltimore, USA


- Assistant Investigator, Division of Gerontology Research, National Health Research Institutes, Taiwan (2004-present)
- Investigator, Central Laboratory, Shin Kong Wu Ho-Su Memorial Hospital, Taiwan (2001-2004)


Dr. Lins research interests include the mammalian cell cycle regulation by cellular stress, and age-related diseases such as cancers and bone defect. His laboratory studies the role of HIF-1α in the invasion and metastasis of human lung adenocarcinoma. He is currently studying the effects of age on cellular mitogenic response of human bone marrow mesenchymal stem cells.


Dr. Lin has published 17 original research articles in the fields of cell biology, molecular biology, and pharmacology.


1.Shyu KG, Hsu FL, Wang MJ, Wang BW and Lin S.* Hypoxia-inducible factor 1? regulates lung adenocarcinoma cell invasion. Exp. Cell Res, 313:1181-1191, 2007. (*=Corresponding Author)
2.Lin S*, Tsai SC, Lee CC, Wang BW and Shyu KG. Berberine inhibits HIF- 1? expression via enhanced proteolysis. Mol. Pharmacology, 66:612-619, 2004. (*=Corresponding Author)
3.Chang H, Shyu KG, Lee CC, Tsai SC, Wang BW, Lee YH and Lin S.* GL331 inhibits HIF-1? expression in a Lung Cancer Model. Biochem. Biophy. Res. Commu., 302:95-100, 2003. (*=Corresponding Author)
4.Lin S*, Shyu KG, Lee CC, Wang BW, Chang CC, Liu YC, Huang FY, and Chang H. Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun., 296:710-715, 2002. (*=Corresponding Author)
5.Lin S, Huang HC, Chen LL, Lee CC and Huang TZ. GL331 induces down-regulation of cyclin D1 expression via enhanced proteolysis and repressed transcription. Mol. Pharmacology, 60:768-775, 2001.
6.Lin S, Wang W, Wilson GM, Yang X, Brewer G, Holbrook N and Gorospe M. Down-regulation of cyclin D1 expression by prostaglandin A2 is mediated by enhanced cyclin D1 mRNA turnover. Mol. Cell. Biology, 20:7903-7913, 2000.
7.Lin S, Hickey R and Malkas L. The biochemical status of the DNA synthesome can distinguish between permanent and temporary cell growth arrest. Cell Growth & Differentiation, 8(12):1359-1369, 1997.
8.Lin S, Hickey R and Malkas L. The isolation of a DNA synthesome from human leukemia cells. Leukemia Research, 21(6):501-512, 1997.