Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Chung-Ho Chang, Ph.D.

Institute of Cellular and Systems Medicine


Ph.D., Biophysics, University of Illinois, Urbana-Champaign, IL, USA
M.S., Physics, National Taiwan University, Taiwan
B.S., Physics, Chung-Yuan University, Taiwan


- Investigator, Division of Gerontology Research, National Health Research Institutes, Taiwan (2006-present)
- Professor, Institute of Medical Research, Chang Jung Christian University, Taiwan (2005-2006)
- Research Consultant, Changhua Christian Hospital, Taiwan (2006-present)
- Associate Professor, Division of Nephrology and Hypertension, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA (1999-2005)
- Assistant Professor, Division of Hypertension, Department of Medicine, and Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA (1991-1999)
- Visiting Assistant Professor, Division of Hypertension, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA (1988-1991)
- Postdoctoral Fellow, Departments of Pharmacology and Cell Biology, Stanford University, Stanford, California, USA (1985-1988)


Professor Chang’s research concerns the molecular mechanisms of the activation of membrane-bound guanylate cyclase (GC-A) by atrial natriuretic factor (ANF or ANP) and antioxidants, and the signaling mechanisms of advanced glycation end products (AGEs). His laboratory has identified several regulatory proteins involved in the ANF, estrogen and AGEs signaling pathways.


Dr. Chang has authored 60 research articles, and is a reviewer for numerous scientific journals. Professor Chang has also reviewed grant applications from the Alberta Heritage Foundation for Medical Research (Canada), National Science Foundation (USA), Veterans Administration (USA), American Heart Association (USA), and National Science Council (Taiwan). He has received research or scholarship awards from the Ohio Kidney Foundation (USA), American Lung Association (USA), and American Heart Association (USA).


  1. Chen, Z.-J., Vetter, M., Chang, G.-D., Liu, S., Ding, Y., and Chang, C.-H. Cyclophilin A functions as an endogenous inhibitor for membrane-bound guanylate cyclase GC-A. Hypertension. 44, 963-968, 2004.
  2. Vetter, M., Chen, Z.-J., Chang, G.-D., Che, D., Liu, S., and Chang, C.-H. Cyclosporin A disrupts bradykinin signaling through superoxide. Hypertension 41, 1136-1142, 2003.
  3. Chen, Z.-J., Miao, Z.-H., Liu, S.,Che, D., Vetter, M., Dulin, N., Douglas, J. G., Murad, F., and Chang, C.-H. Molecular cloning and expression of a regulatory protein for membrane-bound guanylate cyclase. Biochem. Biophys. Res. Commun. 278, 106-111, 2000.
  4. Miao, Z.-H., Song, D.-L., Douglas, J. G., and Chang, C.-H. A single amino acid mutation abolishes the catalytic activity of bacteria expressed catalytic domain of guanylate cyclase-A receptor. Hypertension 25 [2], 694-698, 1995.
  5. Chang, C.-H., and Song, D.-L. Melittin potentiates guanylate cyclase activation stimulated by atrial natriuretic factor and ATP. J. Biol. Chem. 268, 4908-4911, 1993.
  6. Chang, C.-H., Jonas, R., Melchiore, S., Govindjee, R., and Ebrey, T. Mechanism and role of divalent cation binding by bacteriorhodopsin. Biophys. J. 49, 731-739, 1986.
  7. Chang, C.-H., Chen, J.-G., Govindjee, R., and Ebrey, T. Cation binding by bacteriorhodopsin. Proc. Natl. Acad. Sci. USA 82, 396-400, 1985.