Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Charles D Y Sia, Ph.D.

Vaccine Research and Development Center


Ph.D., Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australia, 1981
M.S., Applied Immunology, Brunel University, Uxbridge, UK, 1978
B.Sc., Biochemistry, University of London, UK, 1973


  • Investigator, Vaccine Research and Development Center, National Health Research Institutes, Taiwan (2006-present)
  • General Secretary, SBDR (Society for Biomedical Diabetes Research) (2006-present)
  • Associate Editor of the journal, Reviews of Diabetic Studies (2003- present)
  • Director of Immunology and Vaccinology in UBI (United Biomedical Inc) and subsidiaries (2006)
  • Chief Vaccine Scientist in UBI (USA) and Chief Scientist in UBIAsia (Taiwan) (2003-2005)
  • Senior Scientist, UBI and subsidiaries (2001-2003)
  • Research Scientist, Sinofi Pasteur, Canada (1989-2001)
  • Lecturer, Department of Medical Microbiology, London Hospital Medical College, University of London, England (1988-1989)
  • Lecturer, Department of Immunology, Guys and St Thomas Medical Schools, University of London, England (1984-1988)
  • Scientist, Coral Lab Research, Cambridge, England (1983-1984)
  • Senior Scientific Staff, Medical Research Council, Cambridge, England (1981-1983)


    The first aspect is the investigation of the role of T regulatory cell subsets in disease evolution in human subjects with chronic virus infections using Human Papillomavirus as a study model. The second aspect covers how T regulatory T cells within the immune system interact with other lymphoid cell types leading to their generation and the suppressor function they mediate. The third aspect is directed towards developing strategies to manipulate the level and function of T regulatory cells that can be applied to support the prophylactic and therapeutic vaccine developments at the Vaccine Center in NHRI.


    Dr. Sia is currently the general secretary of the Society for Biomedical Diabetes Research (SBDR). He is also the Associate Editor of the journal, The Reviews in Diabetes Research.
    Dr. Sia has contributed to over 50 scientific papers covering various aspects of Immunology, Viral Immunology, Vaccine design and Autoimmunity in international journals, and filed over 15 patents over the past 17 years, most of these have been granted.


    1.Chang HW, Chow YH, Chong P, Sia C. The Cross-Regulatory Relationship between Human Dendritic and Regulatory T Cells and its Role in Type 1 Diabetes Mellitus. Rev Diabet Stud. 4: 68-76, 2007.
    2.Chen HW, Liu SJ, Chong P, Sia C. The Development and Application of HLA Tetramers in the Detection, Characterization and Therapy of Type 1 Diabetes Mellitus. Rev. Diabetic studies. 3: 51-6, 2007.
    3.Wang CY, Finstad CL, Walfield AM, Sia C, Sokoll KK, Chang TY, Fang XD, Hung CH, Hutter-Paier B, Windisch M. Site-specific UBITh amyloid-beta vaccine for immunotherapy of Alzheimer's disease. Vaccine. 25: 3041-52, 2007.
    4.Sia C. Replenishing Peripheral CD4+ Regulatory T Cells: A Possible Immune-Intervention Strategy in Type 1 Diabetes? Rev Diabetic Stud. 3(3): 102-107, 2006.
    5.Sia C. Arno Hanninen. Aptotosis in autoimmune diabetes: The fate of β-cells in the cleft between life and death. Rev Diabetic Stud. 3: 42-49, 2006.
    6.Sia C. (Editorial article) Is a New Immune Response Mediator in the NF-κB pathway - SUMO-4 - Related to Type 1 Diabetes? Rev Diabetic Stud. 2(2): 58-60, 2005.
    7.Sia C. Michael Weinem. Genetic Susceptibility to Type 1 Diabetes in the Intracellular Pathway of Antigen rocessing - A Subject Review and Cross-Study Comparison. Rev Diabetic Stud. 2(1): 40-52, 2005.