Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Chun-Chin T Liang, Ph.D.

Investigator
Institute of Cellular and Systems Medicine
ctliang@nhri.org.tw

EDUCATION

Ph.D., Biochemistry, Kansas State University, Manhattan, Kansas, USA
M.S., Biochemistry, Kansas State University, Manhattan, Kansas, USA
B.S., Chemistry, Chung-Yuan Christian College, Taiwan

PROFESSIONAL EXPERIENCES

- Investigator, Division of Gerontology Research, National Health Research Institutes, Taiwan (2006 - present)
- Acting Director, Department of Research Planning and Development, National Health Research Institutes, Taiwan (2006)
- Acting Director, Division of Gerontology Research, National Health Research Institutes, Taiwan (2005-2006)
- Associate Director, Department of Intramural Research Affairs, National Health Research Institutes, Taiwan (2004- 2006)
- Visiting Scientist, National Health Research Institutes, Taiwan (1999-2004)
- Acting Chief, Laboratory of Biological Chemistry, Gerontology Research Center, NIA, NIH, Maryland, USA (1994-1996)
- Research Chemist (tenured PI), Laboratory of Biological Chemistry, Gerontology Research Center, NIA, NIH, Maryland, USA (1979-1999)
- Senior Staff Fellow (tenure track), Laboratory of Molecular Aging, Gerontology Research Center, NIA, NIH, Maryland, USA (1976-1979)
- Staff Fellow (tenure track), Laboratory of Molecular Aging, Gerontology Research Center, NIA, NIH, Maryland, USA (1974-1976)
- Research Associate, Department of Physiology and Pharmacology, Duke University Medical Center, North Carolina, USA (1972-1974)
- Graduate Research Assistant, Department of Biochemistry, Kansas State University, Kansas, USA (1968-1972)

RESEARCH INTERESTS

Dr. Liang's research interests are listed as follows:
1. Age-associated changes in bone remodeling activity in vivo and its cellular and molecular mechanisms in vitro
2. Age-associated alterations in osteoprogenitor cells: deficits in mitogenic activity, osteogenic lineage expression and bone induction potential
3. Growth factor, hormone and other novel therapies including MMP inhibitors for osteoporosis
4. Regulatory mechanisms of vitamin D and diets on intestinal absorption and renal reabsorption of Ca and Pi in aging
5. Cellular and molecular mechanisms for desensitization to PTH and its role in impaired Ca and Pi homeostasis in aging

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Liang has been an established researcher on regulatory mechanism of mineral homeostasis in aging. He is the author of 68 articles with many published in excellent journals. His more recent work on the mechanism of impaired osteoprogenitor cells in aging and its corrective remedies has lead to the development of many investigative interventions for postmenopausal as well as age-related osteoporosis.

SELECTED PUBLICATIONS


  1. Tanaka, H., Wakisaka, A., Ogasa, H., Kawai, S., and Liang, C. T. Effect of IGF-I and PDGF administered in vivo on the expression of osteoblast-related genes in old rats. J. Endocrinology. 174:63-70, 2002.
  2. Wakisaka, A., Tanaka, H., Barnes, J., and Liang, C. T. Effect of locally infused IGF-I on femoral gene expression and bone turnover activity in old rats. J. Bone Miner. Res. 13:13-19, 1998.
  3. Williams, S., Wakisaka, A., Zeng, Q. Q., Barnes, J., Martin, G., Wechter, W. J., and Liang, C. T. Minocycline prevents the decrease in bone mineral density and trabecular bone in ovariectomized aged rats. Bone. 19:637-644, 1996.
  4. Quarto, R., Thomas, D., and Liang, C.T. Bone progenitor cell deficits and age-associated decline in bone repair capacity. Calcif. Tissue Int. 56:123-129, 1995.
  5. Liang, C. T., Barnes, J., Takamota, S. and Sacktor, B. Effect of age on calcium uptake in isolated duodenum cells: Role of 1,25(OH)2D3. Endocrinology. 124: 2830-2836, 1989.
  6. Hanai, H., Liang, C. T., Cheng, L. and Sacktor, B. Desensitization to PTH in renal cells from aged rats is associated with alterations in G-protein activity. J. Clin. Invest., 83: 268-277, 1989.
  7. Liang, C. T., Barnes, J., Balakir, R., Cheng, L. and Sacktor, B. In vitro stimulation of phosphate uptake in isolated chick renal cells by 1,25-dihydroxycholecalciferol. Proc. Natl. Acad. Sci. USA 79: 3532-3536, 1982.