Jun-Yang Liou, Ph.D.
Cardiovascular and Blood Research Center
EDUCATION- Ph.D., National Taiwan University, Taiwan
- BS., National Taiwan University, Taiwan
PROFESSIONAL EXPERIENCESAssistant Investigator, Cardiovascular and Blood Research Center, National Health Research Institutes, Taiwan (2007-present)
Assistant Professor, Department of Internal Medicine, Medical School, The University of Texas Health Science Center at Houston, U.S.A.(2005-2007)
Instructor, Department of Internal Medicine, Medical School, The University of Texas Health Science Center at Houston, U.S.A. (2004-2005)
Senior Research Fellow, Department of Internal Medicine, Medical School, The University of Texas Health Science Center at Houston, U.S.A. (2002-2004)
Postdoctoral Fellow, Institute of Biomedical Sciences, Academic Sinica, Taiwan (2000-2002)
Research Fellow, Department of Internal Medicine, Medical School, The University of Texas Health Science Center at Houston, U.S.A. (1999-2000)
Postdoctoral Fellow, Institute of Biomedical Sciences, Academic Sinica, Taiwan (1998-1999)
RESEARCH INTERESTSDr. Liou’s research interests focus on three areas: (1) Signal transduction pathways of cell differentiation and survival for mouse embryonic stem (mES) cells. He has recently discovered signal pathway to commit mouse embryonic stem cell differentiate into neural linage cells. (2) Mechanisms of cancer cell apoptosis and metastasis. Dr. Liou has identified several proteins and signals to control cancer cell migration and survival. (3) Molecular mechanism of endothelial cell survival.
RESEARCH ACTIVITIES & ACCOMPLISHMENTSDr. Liou has demonstrated that COX-2 derived PGE2 protects mES cells from apoptosis through EP2 and PI3K-Akt signal pathway. Further, he has shown multiple mechanisms of PGI2 which include PGI2 transcriptional up-regulates 14-3-3 via PPAR-dependent pathway, phosphorylates XIAP and induces eNOS expression through ERK to protect endothelial cell survival. He has also reported that mitochondrial COX-2 plays an important role for cancer cell survival. Dr. Liou has presented his studies in many international conferences.
HONORS & AWARDSTravel Award of the 8th American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting.
SELECTED PUBLICATIONS1.Liou, J.Y*., Matijevic-Aleksic, N., Lee, S., Wu, K.K. Prostacyclin inhibits endothelial cell XIAP ubiquitination and degradation. Journal of Cellular Physiology. 212:840-848, (2007).
2.Liou, J.Y., Ghelani, D., Yeh, S., Wu, K.K. Non-steroidal anti-inflammation drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3?. Cancer Research. 67:3185-3191, (2007).
3.Liou, J.Y., Ellent, D.P., Lee, S., Goldsby, J., Ko B.S., Matijevic, N., Huang, J.C., Wu, K.K. Cyclooxygenase-2 derived PGE2 protects mouse embryonic stem cells from apoptosis via EP2 and Akt. Stem Cells. 25:1096-1103, (2007).
4.Liou, J.Y., Lee, S., Ghelani, D., Matijevic-Aleksic, N., Wu, K.K. Protection of Endothelial Survival by Peroxisome Proliferator-Activated Receptor-? Mediated 14-3-3 Upregulation. Arterioscler. Thromb. Vasc. Biol. 26:1481-1487, (2006).
5.Liou, J.Y., Aleksic, N., Chen, S.F., Han, T.J., Shyue, S.K., Wu, K.K. Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: Implication in apoptosis resistance. Experimental Cell Research. 306:75-84, (2005).
6.Liou, J,Y., Deng, W.G., Gilroy, D.W., Shyue, S.K., Wu, K.K. Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts. J. Biol. Chem. 276:34975-34982, (2001).
7.Liou, J.Y., Shyue, S.K., Tsai, M.J., Chung, C.L., Chu, K.Y., Wu, K.K. Colocalization of prostacyclin synthase with prostaglandin H synthase-1 (PGHS-1) but not phorbol ester-induced PGHS-2 in cultured endothelial cells. J. Biol. Chem. 275:15314-15320, (2000).
PATENTUS Patent No. 6,168,947. “Nematophagous fungus Esteya vermicola”, 2001.