Shaw-Fang Yet, Ph.D.
EDUCATION-Ph.D., University of Houston, USA
-M.S., National Taiwan University, Taiwan
-B.S., National Taiwan University, Taiwan
PROFESSIONAL EXPERIENCES-Associate Investigator, National Health Research Institutes, Taiwan (2007- present)
-Assistant Professor of Medicine, Brigham and Women's Hospital/Harvard Medical School, USA (2004- 2007)
-Instructor in Medicine, Brigham and Women's Hospital/Harvard Medical School, USA (2000- 2004)
RESEARCH INTERESTSDr. Yet has a long-term interest in cardiovascular biology, particularly in two areas of research: heme oxygenase-1 (HO-1) and oxidative stress associated pathophysiology in cardiovascular system, and transcriptional regulation and functions of vascular smooth muscle cells genes.
Ongoing research projects are 1) investigating the mechanisms by which HO-1 exerts its protective functions, 2) determining the molecular mechanisms by which cysteine-rich protein 2 (CRP2) regulates vascular smooth muscle cell migration, and 3) identifying regulatory modules that control vascular smooth muscle specific expression of CRP2.
RESEARCH ACTIVITIES & ACCOMPLISHMENTSDr. Yet's studies using HO-1 null and transgenic mice have advanced our understanding of the cytoprotective functions of HO-1 in cardiovascular biology. Dr. Yet's laboratory was the first to demonstrate the in vivo function of cysteine-rich protein 2, an arterial smooth muscle cell protein, in vascular disease using genetically modified mice. Dr. Yet serves as reviewer for several major scientific journals. Dr. Yet's research has been funded by grants from National Institutes of Health, American Heart Association, and American Diabetes Association.
SELECTED PUBLICATIONS1. Wei, J., Gorman, T.E., Liu, X., Ith, B., Tseng, A., Chen, Z., Simon, D.I., Layne, M.D., Yet, S.-F. Increased neointima formation in cysteine-rich protein 2–deficient mice in response to vascular injury. Circ. Res. 97(12):1323-31, 2005.
2. Liu, X., Wei, J., Peng, D.H., Layne, M.D., Yet, S.-F. Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice. Diabetes 54(3):778-84, 2005.
3. Chang, Y.-F., Wei, J., Liu, X., Chen, Y.-H., Layne, M.D., Yet, S.-F. Identification of a CArG-independent region of the cysteine-rich protein 2 promoter that directs expression in the developing vasculature. Am. J. Physiol. Heart. Circ. Physiol. 285(4):H1675-83, 2003.
4. Yet, S.-F., Layne, M.D., Liu, X., Chen, Y.-H., Ith, B., Sibinga, N.E.S., Perrella, M.A. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J. 17(12):1759-61, 2003.
5. Yet, S.-F., Tian, R., Layne, M.D., Wang, Z.Y., Maemura, K., Solovyeva, M., Ith, B., Melo, L.G., Zhang, L., Ingwall, J.S., Dzau, V.J., Lee, M.-E., Perrella, M.A. Cardiac specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ. Res. 89(2):168-73, 2001.
6. Yet, S.-F., Perrella, M.A., Layne, M.D., Hsieh, C.-M., Maemura, K., Kobzik, L., Wiesel, P., Christou, H., Kourembanas, S., Lee, M.-E. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J. Clin. Invest. 103(8):R23-9, 1999.
7. Yet, S.-F., Folta, S.C., Jain, M.K., Hsieh, C.-M., Maemura, K., Layne, M.D., Zhang, D., Marria, P.B., Yoshizumi, M., Chin, M.T., Perrella, M.A., Lee, M.-E. Molecular cloning, characterization, and promoter analysis of the mouse CRP2/SmLIM gene: preferential expression of its promoter in the vascular smooth muscle cells of transgenic mice. J. Biol. Chem. 273(17):10530-7, 1998.