Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Yu-Li Liu, Ph.D.

Assistant Investigator
Institute of Population Health Sciences


- Ph.D., Department of Pharmacology, East Tennessee State University, Johnson City, TN, USA (1997)
- M.S., Department of Pharmacology, National Yang Ming Medical College, Taipei, Taiwan (1987)


- Research Associate, Division of Mental Health and Substance Abuse Research, National Health Research Institute, Taiwan
-Post-doctor, Department of Medical Research/Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
- Clinical Researcher, Department of Education and Research Center, Shin Kong WHS Memorial Hospital, Taipei, Taiwan


Yu-Li's research interest is mainly in molecular schizophrenia search. This include of candidate genes searching, functional verification, and treatment monitoring. Until now, she have worked with the schizophrenia research team leading by Professor Hai-Gwo Hwu at National Taiwan University Hospital and National Taiwan College of Medicine and discovered several schizophrenia candidate genes in the population of Taiwan. After joining the Division of Mental Health and Substance Abuse Research in NHRI, she started working with other research team and searching for the refractory schizophrenia. She is now looking for the factors contributing to the treatment response.


Yu-Li was joining the division at March 1, 2006. She has published 9 papers in searching schizophrenia candidate genes since 2005. She has one paper published in the field of alcoholism, one paper co-operating with the dermatologist on the dopaminergic effect on skin pigment cell melanocytes (a neural crest derived cell), and one paper examining the effect of antidepressants on cultured neurotransmitter-secreting colon cancer cells. Yu-Li is now organizing the therapeutic drug monitoring (TDM) system for the division to assess if a patient takes enough dose of medicine for the treatment of psychiatric illness, including schizophrenia.


1. Liu, YL, Fann, CSJ, Liu, CM, Yang, WC, Wu, JY, Hung, SI, Chan, HY, Chen, JJ, Liu, SK, Shieh, MH, Hwang, TJ, OuYang, WC, Chen, CY, Lin, JJ, Chou, FHC, Chueh, CM, Liu, WM, Tsuang, MM, Faraone, SV, Tsuang, MT, Chen, WJ, and Hwu, HG: (2007) More evidence supports the association of PPP3CC with schizophrenia. Mol. Psychiatry. 12(10): 966-974.

2. Liu, YL, Fann, CSJ, Liu, CM, Chang, CC, Yang, WC, Wu, JY, Hung, SI, Chan, HY, Chen, JJ, Hsieh, MH, Hwang, TJ, Faraone, SV, Tsuang, MT, Chen, WJ and Hwu, HG: (2007) HTF9C Gene of 22q11.21 Region Associates with Schizophrenia Having Deficit Sustained Attention. Psych. Gen. 17(6): 333-338.

3. Liu, YL, Fann, CSJ, Liu, CM, Chen, WJ, Wu, JY, Hung, SI, Chen, JH, Jou, YS, Liu, SK, Hwang, TJ, Hsieh, MH, Ou-Yang, WC, Chan, HY, Chen, JJ, Yang, WC, Lin, CY, Lee, SFC and Hwu, HG: (2006) A SNP Fine Mapping Study on Chromosome 1q42.1 Reveals Vulnerability Genes of GNPAT and DISC1 in Schizophrenia: Association with Impairment of Sustained Attention. Biol. Psych. 60: 554-562.

4. Liu, YL, Fann, CSJ, Liu, CM, Chang, CC, Wu, JY, Hung, SI, Liu, SK, Hsieh, MH, Hwang, TJ, Chan, HY, Chen, JJ, Faraone, SV, Tsuang, MT, Chen, WJ, and Hwu, HG: (2006) No Association of G72 and D-Amino Acid Oxidase Genes with Schizophrenia. Schizophr. Res. 87: 15-20.

5. Yue, CT, and Liu, YL: (2005) Fluoxetine increases extracellular levels of 3-methoxy-4- hydroxyphenylglycol in cultured COLO320 DM cells. Cell Biochem. Func 23: 109-114.