Ching-Yu Huang, Ph. D.
Immunology Research Center
EDUCATION- Ph.D., Program in Immunology, Division of Biology and Biomedical Science, Washington University, St. Louis, MO, USA, 2002.
- B.S., Division of Fishery and Wildlife, Department of Zoology, National Taiwan University, Taipei, Taiwan, 1992.
PROFESSIONAL EXPERIENCESAssistant Investigator, Immunology Research Center, National Health Research Institute, Taiwan (2007-present)
Postdoctoral Research Scholar, Department of Pathology and Immunology, School of Medicine, Washington University, St. Louis, MO, USA (2003-2007)
Research Associate, Department of Pathology and Immunology, School of Medicine, Washington University, St. Louis, MO, USA (2002-2003)
RESEARCH INTERESTSThe functions of CD4 helper T cells are critical for the regulation of immune responses. Of the currently defined CD4 helper cell subsets, Th17, which secrets the inflammatory cytokine IL-17, has been correlated with immune disregulation and the onset of autoimmune diseases. Interestingly, the condition for in vitro differentiation of Th17 is very similar to that of the differentiation of another CD4 helper T cell subset, Treg, which has been shown to suppress immune responses and potentially alleviate autoimmune syndromes.
To study the differentiation of Th17 cells and their roles in immune regulation, Dr. Huang’s laboratory will generate several novel mouse models in two perspectives. First, a reporter mouse in which differentiated Th17 cells will be marked by the expression of fluorescent proteins should allow identification and isolation of Th17 cells for downstream biochemical, genomic, and proteomic studies. Secondly, the generation of various conditional mutations of signaling molecules in the MAPK pathway, which is important for proliferation, survival and activation of T cells, will facilitate assessment of the signaling networks for Th17 differentiation and functions. Through the generation of these novel systems, Dr. Huang wish to establish cutting-edge researches on Th17 cells here at NHRI, incite extramural collaborations with other immunologists, and contribute to further promote immunological studies in Taiwan.
RESEARCH ACTIVITIES & ACCOMPLISHMENTSDr. Huang’s earlier publications focus on investigating the regulation of T cell receptor (TCR)
SELECTED PUBLICATIONS1.Huang C, Bredemeyer AL and Sleckman BP. Dynamic expression of c-Myc proto-oncogene lymphocyte development. In press.
2.Huang C, and Sleckman BP. Developmental stage-specific regulation of TCR chain gene assembly by intrinsic features of the TEA promoter, J Immunol. 2007. 179:449-454.
3.Huang C, Sharma GG, Walker LM, Bassing CH, Pandita TK and Sleckman BP. Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes, J Exp Med. 2007. 204:1371-1381
4.Bredemeyer AL, Sharma GG, Huang C, Helmink BA, Walker LM, Khor KC, Nuskey B, Sullivan KE, Pandita TK, Bassing CH and Sleckman BP. ATM stabilize DNA double-strand-break complexes during V(D)J recombination, Nature 2006. 442: 466-470.
5.Huang C, Sleckman BP and Kanagawa O. Revision of T cell receptor chain genes is required for normal T lymphocyte development, Proc Natl Acad Sci U S A. 2005. 102:14356-61.
6.Huang C and Kanagawa O. Ordered and coordinated rearrangement of the TCR ? locus: role of secondary rearrangement in thymic selection. J Immunol. 2001. 166:2597-601.
7.Wang F, Huang C and Kanagawa O. Rapid deletion of rearranged T cell antigen receptor (TCR) V?-J? segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR ? chain gene and positive selection in the T cell repertoire formation. Proc Natl Acad Sci U S A. 1998. 95:11834-9.