Jinq-Chyi Lee, Ph.D.
Institute of Biotechnology and Pharmaceutical Research
EDUCATIONPh.D., Chemistry, National Tsing Hua University, Taiwan, 2003
B.A., Chemistry, National Sun Yat-Sen University, Taiwan, 1998
PROFESSIONAL EXPERIENCESAssociate Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes (2013- present)
Assistant Investigator, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes (2008-2012)
Research Associate, Department of Chemistry, The Scripps Research Institutes, USA (2004-2007)
Postdoctoral Fellow, Institute of Chemistry, Academia Sinica, Taiwan (2003-2004)
RESEARCH INTERESTSThe main focus of Dr. Lee's research is on drug discovery of SGLT2 inhibitors for the treatment of type 2 diabetes. SGLT2, sodium-dependent glucose cotransporter 2, is a membrane protein located in the proximal tubule of the kidney and is responsible for the reabsorption of glucose from the glomerular filtrate to the plasma. By preventing the reuptake of glucose, inhibitors of SGLT2 result in the elevated urinary glucose excretion. In the clinic, such agents have been proven to reduce plasma glucose levels in diabetic patients.
RESEARCH ACTIVITIES & ACCOMPLISHMENTSDr. Lee has finished the synthesis of heparin oligosaccharides and N3 minor cancer antigen. She has also finished the screening of novel
SELECTED PUBLICATIONS1.Northen TR, Lee JC, Hoang L, Raymond J, Hwang DR, Yannone SM, Wong CH and Siuzdak G. A Nanostructure-Initiator Mass Spectrometry Based Enzyme Activity Assay. Proc. Nat. Acad. Sci. U.S.A., 2008 (in press).
2.Wang CC, Kulkarni SS, Lee JC, Luo SY and Hung SC. Regioselective one-pot protection of glucose. Nature Protocols., 2: 97-113. 2008.
3.Wang CC, Lee JC, Luo SY, Kulkarni SS, Huang YW, Lee CC, Chang KL and Hung SC. Regoselective one-pot protection of carbohydrates. Nature, 446: 896-899, 2007.
4.Lee JC, Greenberg WA and Wong CH. Programmable Reactivity-Based One-Pot Oligosaccharide Synthesis. Nature Protocols, 1: 3143-3152, 2006.
5.Lee JC, Wu CY, Apon JV, Siuzdak G and Wong CH. Reactivity-Based One-Pot Synthesis of the Tumor-Associated Antigen N3 Minor Octasaccharide for the Development of a Photocleavable DIOS-MS Sugar Array. Angew. Chem. Int. Ed., 45: 2753-2757. 2006.
6.Lee JC, Pan GR, Luo SY, Kulkarni SS, Liao CC and Hung SC. 2-Allyloxyphenyl Glycoside as a New and Stable Type of Glycosyl Donors. Tetrahedron Lett., 47: 1621-1624. 2006.
7.Lee JC, Lu XA, Kulkarni SS, Wen YS and Hung SC. Synthesis of Heparin Oligosaccharides. J. Am. Chem. Soc., 126: 476-477. 2004.
8.Lee JC, Chang SW, Chi FC, Chen CS, Wen YS, Wang CC, Kulkarni SS, Puranik R, Liu YH and Hung SC. From D-Glucose to Biologically Potent L-Hexoses: Synthesis of ?-L-Iduronidase Fluorogenic Detector and the Disaccharide Moieties of Bleomycin A2 and Heparan Sulfate. Chem. Eur. J., 10: 399-415. 2004.
9.Kulkarni SS, Lee JC and Hung SC. Recent Advances in the Applications of D- and L-1,6-Anhydropyranoses for the Synthesis of Oligosaccharides and Natural Products. Curr. Org. Chem., 8: 475-509. 2004.
10.Wang CC, Lee JC, Luo SY, Fan HF, Pai CL, Yang WC, Lu LD and Hung SC. Synthesis of Biologicaally Potent ?1
PATENTUS Patent No. 2006079438 “Heparin oligosaccharides”; April 13, 2006.