Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Mandy Hui-Ju Ch'ang, M.D.

Assistant Investigator and Attending Physician
National Institute of Cancer Research
hjmc@nhri.org.tw

EDUCATION

M.D., Department of Medicine, College of Medicine, National Taiwan University, Taiwan, 1988

PROFESSIONAL EXPERIENCES


  • Assistant Investigator and Attending Physician, National Institute of Cancer Research, National Health Research Institutes, Taiwan (2005-present)

  • Attending Physician, Division of Cancer Research, National Health Research Institutes, Taiwan (2000-2005)

  • Research Fellow and Clinical Observer, Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, USA (2000-2002)

  • Research Fellow, Division of Cancer Research, National Health Research Institutes, Taiwan (1999-2000)

  • Resident, Radiation Oncology, Sun Yat-Sen Cancer Center, Taiwan (1995-1998)

  • Resident, Medical Oncology, National Taiwan University Hospital, Taiwan (1992-1994)

  • Resident, Internal Medicine, National Taiwan University Hospital, Taiwan (1989-1992)

RESEARCH INTERESTS

As a radiation oncologists, Dr. Ch'ang is interested in clinical radiation as well as modern radiation biology of hepatobilliary and gastrointestinal malignancies. Her laboratory work is majoring in the contribution of bone marrow stem cells in intestinal repair after radiation. Similar studies are developed for studying bone marrow stem cells with tumor microenvironment after radiation. She is also interested in investigating combination effect of molecular targeting agents and radiation. Besides animal studies, she designed clinical studies for hepatocellular carcinoma patients undergoing local radiation. The blood perfusion within tumor was measured by dynamic contrast enhanced magnetic resonance imaging before, during and after radiation treatment course. A series of clinical trials for pancreatic cancer patients were also initiated by Dr. Ch'ang in collaboration with Professor Li-Tzong Chen.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Ch'ang focused her basic research on radiation related normal tissue toxicity using intestinal tract of mice as a model. She published a cutting edge research report on Nature Medicine regarding target switching of intestinal tissue to radiation. Currently, her basic research project was supported by NHRI grant CA-96-PP-08 entitled: Mobilization of Bone Marrow Stem Cells and Cancer Cells by Granulocyte Colony-Stimulating Factor in Cancer Therapy. Dr. Ch'ang is also dedicated to clinical research regarding combine modality therapy especially for hepatobiliary and gastrointestinal tract cancer. Currently, there are several clinical trials are undergoing: 1. A phase II study of concurrent chemoradiation for the untreated, localized nasal NK/T-cell lymphoma (2005-present) 2. A phase II trial of local irradiation plus oral thalidomide in hepatocellular carcinoma. (2005-present) 3. A phase II study of induction chemotherapy followed by concurrent chemotherapy with radiotherapy in locally advanced pancreatic cancer (2004-present)

HONORS & AWARDS

Scholar-in-Training Award for Promising Cancer Research, AACR-ITO EN, Ltd. at the 93rd AACR Annual Meeting, USA, 2002

SELECTED PUBLICATIONS


  1. Liang PC*, Ch'ang HJ*, Hsu C, Tseng SS,Shih STF and Liu TW. (*equal contribution) Dynamic MRI Singlas in the Second Week of Radiotherapy Related to Treatment Outcomes of Hepatocellular Carcinoma A Preliminary Result. Liver International, 27(4): 516-28, 2007

  2. Ch'ang HJ*, Wang CC, Cheng AL, Hsu C, Lu YS, Chang MC, Lin JT, Wang HP, Liu TW, Chang JY, Whang-Peng J and Chen LT. Phase I Study of Biweekly Gemcitabine followed by Oxaliplatin and Simplified 48-hr infusion of Fluorouracil/Leucovorin (GOFL) for Advanced Pancreatic Cancer. J Gastroenterol Hepatol, 21(5): 874-9, 2006.

  3. Ch'ang HJ, Maj J G., Paris F, Xing H. R, Zhang J, Truman JP, Cardon-Cardo C, Friedman AH, Kolesnick R and Fuks Z. ATM Regulates Target Switching to Escalating Doses of Radiation in the Intestines. Nature Medicine, 11(5) : 484-490, 2005.

  4. Ch'ang HJ, Jian JJM, Cheng SH, Liu MC, Leu SY, Wang FM, Tsai S YC, Tsao MH, Lin HH, Huang A T and Sung JL. Preoperative Concurrent Chemotherapy and Radiotherapy in Rectal Cancer Patients. Formos. Med. Assoc, 97:32-7, 1998.

  5. Ch'ang HJ, Su IJ, Chen CL, Chiang IP, Chen YC, Wang CH and Cheng AL. Angioimmunoblastic Lymphadenopathy with Dysproteinemia-Lack of a Prognostic Value of Clear Cell Morphology. Oncology, 54: 193-8, 1997.

  6. Ch'ang HJ, Cheng SH, Liu MC, Jian JJM and Chen CM. Postoperative Concurrent Chemotherapy and Radiotherapy for Resectable Locally advanced Gastric Cancer Patients-A preliminary Report. Therapeutic Radiology and Oncology, 4(3): 195-201, 1997.

  7. Ch'ang HJ, Tien HF, Wang CH, Chuang SM and Chen YC. Comparison of Clinical and Biologic Features between Myeloid and Lymphoid Transformation of Philadelphia Chromosome Positive Chronic Myeloid Leukemia. Cancer Genet. Cytogenet, 71: 87-93, 1993.