Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Sheau-Ling Lee, Ph.D.

Assistant Investigator
Institute of Cellular and Systems Medicine
sllee@nhri.org.tw

EDUCATION

Ph.D., Mole. Biol. and Biochem., University of OK. Health Sciences Center, USA, 1996

PROFESSIONAL EXPERIENCES

  • Assistant Investigator, Stem Cell Research Center, National Health Research Institutes, Taiwan (2005)
  • Instructor, Dept. of Onco., Lombardi Comprehensive Cancer Center, Georgetown Univ. School of Medicine, Washington, DC, USA (2001)
  • Postdoctoral Fellow, Dept. of Onco., Lombardi Comprehensive Cancer Center, Georgetown Univ. School of Medicine, Washington, DC, USA (1999)
  • Postdoctoral Fellow, Henry Hood Research Program, Weis Center for Research, Penn. State Univ. College of Medicine, PA, USA (1997)

    RESEARCH INTERESTS

    Dr. Lees research of interest is on the identification of human disease targets in stem cell regulation, signal transduction, cell cycle control, and epithelial-mesenchymal interaction. Specific topics at present time are focused on the molecular and cellular events of the stem cell microenvironment, known as niche, in health and disease. In the brain model, Dr. Lees team is interested in the mechanisms and the various cell types that participate in neural stem/progenitor cells mobilization/ migration and their modulation in brain disorders. One focus is the extracellular proteolytic activation events in neural stem cells movement. Dr. Lees studies in breast are to identify the molecular and structural characteristics of mammary epithelial stem cell niches, how they behave during normal breast function, and how they affect or are affected in breast cancer tumorigenesis.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Lees research activities, over the years, have covered diverse areas such as protein kinases and ubiqutin-proteasome of protein maturation and cell cycle checkpoint controls, extracellular matrix proteolysis and cell-cell interaction of cancer progression, enzyme kinetics and anti-cancer drug screening. Dr. Lee is one of the few who can identify mammary epithelial stem cell and its niche in tissue by histology in their natural context. This ability allows to visualize each cell type, and to analyze the behavior of the stem/progenitor cells and their residing niches under complex physiological cues in vivo. For current research goals, Dr. Lees team is applying tissue histochemical analysis, animal models as well as molecular biological and biochemistry approaches in cell cultures/co-culture of embryonic stem cells and adult stem cells.

    SELECTED PUBLICATIONS

    1.Li P, Jiang S, Lee SL, Lin CY, Johnson MD, Dickson RB, Michejda CJ and Roller PP. Design and Synthesis of Novel and Potent Inhibitors of the Type II Transmembrane Serine Protease, Matriptase, Based upon the Sunflower Trypsin Inhibitor-1, J Med Chem. Epub ahead of print, 2007
    2.Jiang S, Li P, Lee SL, Lin CY, Long YQ, Johnson MD, Dickson RB and Roller PP. Design and synthesis of redox stable snalogues of sunfiower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase. Org. Lett, 9(1): 9-12, 2007.

    PATENT

    US patent No: 6,677,377 "Structure-based discovery of inhibitors of matriptase for the treatment of cancer and other conditions"; Issue date: Jan 13, 2004,