Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Suh-Chin Wu, Ph.D.

Adjunct Associate Investigator
Vaccine Research and Development Center
scwu@life.nthu.edu.tw

EDUCATION

  • Ph.D., Chemical Eng, Texas A&M University, Taiwan, 1993
  • M.S., Chemical Eng, National Tsing Hua University, Taiwan, 1987
  • B.S., Chemical Eng, National Cheng Kung University, Taiwan, 1985

    PROFESSIONAL EXPERIENCES

  • Visiting Professor, Biological Resource Branch, National Cancer Institute, National Institutes of Health, USA (2008)
  • Professor/Assoicate Professor/Assistant Professor, Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Taiwan (1997-present)
  • Associate Investigator, National Institute of Preventive Medicine, Taiwan (1995-1997)
  • Visiting Fellow, National Center for Biotechnology Information (jointed with National Cancer Institute), National Institutes of Health, USA (1994-1995)

    RESEARCH INTERESTS

    Dr. Wus research interests are in the areas of cell culture engineering and molecular viral vaccines. He has been working on developing serum-free microcarrier cell cultures for inactivated vaccines (JE, EV71, H5N1) and also characterizing the replication interference effects on regulatory cell lines, immune cells or in animal models related to the development of live-attenuated tetravalent dengue vaccines. Another interest is on the structure-functional studies of two flavivirus envelope glycoproteins in the particle biogenesis, assembly, and cell fusion processes.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Wu has developed serum-free Vero cell culture processes for inactivated Japanese encephalitis and enterovirus type 71 vaccine developments. He also succeeded in identifying a novel target for RNA interference to improve the expression level and stability of recombinant IgG in the gene-amplified stable CHO cells.

    HONORS & AWARDS

  • Maquis Whos Who in the World, Science and Engineering, Aisa (2001, 2004, 2007)
  • Recipient of the Nakajima Foundation, Japan, 2001
  • Editorial board, Enzyme and Microbial Technology (2005-present)
  • Editorial board, International Journal of Medical Engineering and Informatics (2007-present)

    SELECTED PUBLICATIONS

    1.Hong WW, Wu SC*. A novel RNA silencing vector to improve antigen expression and stability in Chinese hamster ovary cells. Vaccine 2007; 25(20): 4103-11. (*=Corresponding Author)

    2.Liu CC, Lian WC, Butler M, Wu SC*. High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture, Vaccine 2007; 25(1): 19-24. (*=Corresponding Author)

    3.Chang CY, Hong W, Chong P, Wu SC* Influence of intron and exon splicing enhancers on mammalian cell expression of a truncated spike protein of SARS-CoV and its implication for subunit vaccine development, Vaccine 2006; 24(8): 1132-41. (*=Corresponding Author)

    4.Lin YJ, Wu SC* (2005) Histidine at residue 99 and the transmembrane region of the precursor membrane prM protein are important for the prM-E heterodimeric complex formation of Japanese encephalitis virus. Journal of Virology 79(13): 8535-44. (*=Corresponding Author)

    5.Wu SC*, Liu CC, Lian WC (2004) Optimization of microcarrier cell culture process for the inactivated enterovirus type 71 vaccine development. Vaccine 22, 3858-3864. (*=Corresponding Author)

    6.Lin CW, Wu SC* (2003) A functional epitope determinant on domain III of the Japanese encephalitis virus envelope protein interacted with the neutralizing antibody combining sites. Journal of Virology 77, 2600-2606. (*=Corresponding Author)

    7.Wu SC*, Yu CH, Lin CW, Chu IM (2003) The domain III fragment of Japanese encephalitis virus envelope protein: mouse immunogenicity and liposome adjuvanticity. Vaccine 21, 2516-1522. (*=Corresponding Author)