Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Wei-Cheng Lian, BVM, Ph D.

Adjunct Assistant Investigator
Vaccine Research and Development Center
wcl@cdc.gov.tw

EDUCATION

  • Ph D., Veterinary Medicine, National Taiwan University, 1994
  • BVM, Veterinary Medicine, National Taiwan University, 1988

    PROFESSIONAL EXPERIENCES

  • Chief of Production section, Vaccine center, CDC (2003-present)
  • Associate investigator, Vaccine center, CDC (2002-2003)
  • Assistant investigator, Vaccine center, Centers for Disease Control, Department of Health (1999-2002)

    RESEARCH INTERESTS

    Dr. Lians research interests in the areas of vaccinology and virology. He worked out an approach for virus vaccines including cell-based Japanese encephalitis virus vaccine and enterovirus type 71 vaccine. He has participated in a development project to prepare re-assortment H5N1 influenza virus banks as vaccine reference.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Lian presently manages a factory, which conforms to current Good Manufacturing Practice regulations, for production of vaccine and antivenom for human use. He and colleagues of production section have refined the manufacturing processes in order to enhance the purity and potency of these biological products. These products are distributed in the domestic market so far.

    SELECTED PUBLICATIONS

    1.Liu CC, Lian WC, Butler M, Wu SC. High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture. Vaccine 25: 19-24, 2007. (SCI)

    2.Tsai MS, Chiu YT, Wang SH, Hsieh-Li HM, Lian WC, Li H. Abolishing Bax-dependent apoptosis shows beneficial effects on spinal muscular atrophy model mice. Molecular Therapy 13(6): 1149-1155, 2006. (SCI)

    3.Li H, Tsai MS, Chen CY, Lian WC, Chiu YT, Chen GD, Wang SH. A novel maternally transcribed homeobox gene, Eso-1, is preferentially expressed in oocytes and regulated by cytoplasmic polyadenylation. Molecular Reproduction and Development 73(7): 825-833, 2006. (SCI)

    4.SJ Liu, CH Leng, SP Lien, HY Chi, CY Huang, CL Lin, WC Lian, CJ Chen, SL Hsieh, Pele Chong. Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates. Vaccine 24: 3100-3108, 2006. (SCI)

    5.SC Wu, CC Liu, Lian WC. Optimization of micro-carrier cell culture for the inactivated enterovirus 71 vaccine development. Vaccine 22: 3858-3864, 2004. (SCI)