Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Shih-Liang Hsieh, Ph.D.

Adjunct Investigator
Vaccine Research and Development Center
slhsieh@ym.edu.tw

EDUCATION

  • Ph.D., Biochemistry, University of Oxford, UK, 1992
  • M.D., Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan, 1988
  • B.S., School of Medicine, National Yang-Ming University, Taipei, Taiwan, 1984

    PROFESSIONAL EXPERIENCES

  • Head, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan (2005-2007)
  • Director, Immunology Research Center, Taipei Veterans’ General Hospital, Taiwan (2005-present)
  • Co-appointed Senior Investigator, National Health Research Center, Taipei, Taiwan (2005-present)
  • Visiting Scholar, The Scripps Research Center (2006/07/01 ~ 2006/09/12), hosted by Professor James Paulson
  • Director, Department of Education and Research, Taipei City Hospital, Taipei, Taiwan (2004-2005)
  • Deputy Director, Department of Medicine, Natl. Yang-Ming Univ., Taipei, Taiwan (2003-2004)
  • Professor, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan (2001-present)
  • Director, Immunology Research Center, Natl. Yang-Ming Univ., Taipei, Taiwan (2000-present)
  • Visiting Scholar, Stanford University (1998/07/01 ~ 1998/09/12), hosted by Professor Hugh McDevitt
  • Visiting Scholar, DNAX, Palo Alto (1998/07/01 ~ 1998/09/12), hosted by Professor Yung-Jun Liu
  • Visiting Scholar , Scripps Research Institute, San Diego (1998/07/01 ~ 1998/09/12), hosted by Professor Chi-Huey Wong (President of Academia Sinica)
  • Associate Professor, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan (1994-2000)
  • Post-doc fellow, Department of Microbiology and Immunology, Stanford University School of Medicine, USA (1993-1994)
  • Lecturer, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan (1988-1989)
  • Teaching assistant, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan (1986-1988)

    RESEARCH INTERESTS

    Immunosuppressive effects of decoy receptor 3 (DcR3)

    Dr. Hsieh has focused on the understanding how Decoy receptor 3 (DcR3) to modulate host immunity. DcR3 is overexpressed by tumor cells and is able to modulate host immune response via 1) neutralizing FasL, LIGHT and TL1A; and 2) crosslinking of HSPG on cell surface. The molecular mechanism of DcR3 to drive macrophage into M2 haplotype is being analyzed using microarray to identify genes modulated by DcR3.

    Host-pathogen interaction: Role of C-type lectin and Ig-like receptors in viral infection

    Incubation of viruses with macrophages can stimulate cytokine release. Dr. Hsieh is interested to know whether viral particles can act as ligands to stimulate immune cells via binding to organ receptors expressed on myeloid cells, such as C-type lectins and Ig-like receptors. The identification of virus recognition receptor is important to alleviate inflammatory reaction and prevent tissue damage and host mortality.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Hsieh is on the pioneers to elucidate the unique functions of DcR3 is via crosslinking of HSPG. This leads to a novel idea to modulate immune system via targeting HSPG to suppress host immunity for the treatment of human diseases.
    Dr. Hsieh is also the pioneer to elucidate the mechanism of viral infection and acute inflammatory reaction, which can be explained by two aspects: the presence of innate immunity receptor and entry receptor for virus. This provide a new concept to curb vial infection not only via blockade of virus entry, but also via inhibition of virus binding to recognition receptor.

    HONORS & AWARDS

  • Distinguished Professor, National Yang-Ming University, 2007-2011
  • Outstanding Alumnus, National Yang-Ming University, 2004
  • Outstanding Researcher Award from the National Science Council, 2003
  • Outstanding Researcher Award from the National Science Council, 1999
  • Irvington Medial Foundation post-doctoral fellowship for 3 years, ‘Robert Wood Johnson Fellow’, 1992
  • Oversea Research Scholarship (ORS) from the University of Oxford, 1989-1992
  • Oversea PhD studentship from the Ministry of Education, 1989-1992

    SELECTED PUBLICATIONS

    1.Chang YC, Chen TC, Wang HW, Lai MZ, Hsieh SL*. Suppression of MHC Class II Expression via Histone Deacetylation of CIITA Promoter by Decoy Receptor 3 (DcR3), 2007 (submitted)(*=Corresponding Author)

    2.Chen ST, Lin YL, Huang MT, Wu MF, Cheng SC, Lei HY, Lee CK, Wong CH, Hsieh SL*. CLEC5A is Critical for Dengue Virus-Induced Lethal Disease, 2007, Nature (revision) (*=Corresponding Author)

    3.You RI, Chang YC, Hsu TL, Hsieh SL*. Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3), Blood First Edition Paper, prepublished online November 15, 2007; DOI 10.1182/blood-2007-09-114850 (*=Corresponding Author)

    4.Tang CH, Hsu TL, Lin WW, Lai MZ, Yang RS, Hsieh SL* and Fu WM*. Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice. J Biol Chem; 282(4): 2346-2354*, 2007 (*=Corresponding Author)

    5.How CK, Chern CH, Wu MF, Wang LM, Huang CI, Lee CH and Hsieh SL*. Expression of the triggering receptor expressed on myeloid cells-1 mRNA in a heterogeneous infected population. Intl J Clin Pra doi: 10.1111/j.1742-1241.2006.01193.x (SCI), 2007 (*=Corresponding Author)

    6.You RI, Chen MC, Wang HW and Hsieh SL*. Inhibition of Lymphotoxin-beta Receptor (LT

    PATENT

  • Fingerprinting of Polysaccharides and Virions by Innate Immunity Receptors (pending)
  • Methods and reagents for the analysis and purification of polysaccharides (pending)
  • US Patent No. 6,689,867 B1 "Placenta Derived Apoptosis Factor" (PDAF); Granted (2004)
  • ROC Patent No. 133636, "Invention of mAb against human lymphotoxin-beta receptor"; Granted (2001)