Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Louis W. Chang, M.S., Ph.D.

Investigator & Founding Director
Division of Environmental Health and Occupational Medicine
lwchang44 @nhri.org.tw; lwchang44@yahoo.com

EDUCATION

- B.A. (Biol./Chemistry), Univ. of Massachusetts Amherst, 1966
- M.S. (Anatomy/Histochemistry), Tufts Univ./Harvard Medical School, 1969
- Ph.D. (Toxicopathology/Neuroscience), University of Wisconsin-Madison, 1972
- Visiting Scholar (Neurotoxicology), Brain Res. Inst., Univ. of Calif.-Los Angeles, 1987
- Certification on Full Professorship, Department of Education, Taiwan, ROC, 2006
- Diplomat, American Board of Forensic Examiners (DABFE), 1996
- Diplomat, American Board of Forensic Medicine (DABFM), 1996
- Fellow, Academy of Toxicological Sciences (FATS), 1995

PROFESSIONAL EXPERIENCES

- Investigator, Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taiwan (1999-present)
- Adjunct Professor, Occupational Safety and Health, Chung-Shan Medical University, Taiwan (2004 present)
- Founding Director, Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taiwan (1999-2004)
- Emeritus Professor of Pathology, University of Arkansas for Medical Sciences, USA (2000-present)
- Professor of Pathology, Pharmacology/Toxicology, Univ. of Arkansas for Medical Sciences, USA (1980 2000)
- Director of Pathology Graduate Program, University of Arkansas for Medical Sciences, USA (1980-2000)
- Director of Interdisciplinary Toxicology Program, University of Arkansas for Medical Sciences, USA (1988 - 1990)
- Founding Director of Pathophysiology Ph.D. Program, University of Arkansas for Medical Sciences, USA (1997 - 1999)
- Founding member of Immunopathology Graduate Program, University of Arkansas for Medical Sciences, USA (1998-1999)
- Assoc. Prof. & Founding Director of Pathology Graduate Program, Univ. of Arkansas for Medical Sciences, USA (1978-1980)l Assistant Prof. of Pathology & Director of Histopathology Laboratories, Univ. of Wisconsin Medical School, USA (1972 1977)
- Assistant Professor of Pathology, University of Wisconsin Medical School, USA (1972-1977)

RESEARCH INTERESTS

Prof. Chang's research interests and expertise are broad and diversified, including heavy metal toxicology, experimental pathology, neurotoxicology/neuropathology, POPs (PCBs dioxins, etc.) research, endocrine disruptors, environmental carcinogenesis and cardiovascular diseases. Recent research by the Chang's group at NHRI discovered a novel pathophsiological mechanism induced by arsenic in-vivo. This mechanism involved arsenic-induced neurogenic-release of substance P and subsequent NK-1 receptor activation. This discovery provided new concepts and implications on arsenic induced vascular changes and carcinogenesis in humans. Research efforts by Prof. Chang and his collaborators at NHRI also unveiled important scientific information on roles of common environmental factors (cooking oil fume, dioxins, motorcycle exhausts, etc.) in relationship to female lung cancer development. In addition, Prof. Changs research team at NHRI further conducted animal studies to explore synergistic interactions between cigarette smoke and environmental factors, such as dioxins and arsenic, in the enhancements of lung cancer development which is becoming an alarming health concern in Taiwan. In recent years, Prof. Chang also initiated the Nanotoxicology Program at the NanoMedicine Research Center at NHRI providing research on safety evaluations on nanoparticles and materials.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Professor Chang is an internationally recognized scientist, especially in the field of heavy metal toxicology, toxicopathology, neurotoxicology, and environmental carcinogenesis. He has a distinguished and prolific scientific career with over 400 publications, 20 review articles, 60 book-chapters, and 9 textbooks on metal and neurotoxicology under his credit. He has served as members to many major scientific and medical societies and was the past-President of the American-Chinese Toxicology Society in USA. Aside having served on editorial boards or as Managing Editor for many top rated scientific journals, Prof. Chang has also served on the advisory board and review committees for several major US governmental agencies, including EPA, NCTR, NIOSH, NIEHS, FDA, and CDC. He has also served as consultants to various industries in USA. Thus, he possesses a rich and rare combination of experiences in both academia, government, and industry. Prof. Chang has organized and participated in numerous international conferences, symposia, and workshop with tremendous international outreach and networking experience. Aside being a prolific scientist, Prof. Chang is an accomplished educator. He was instrumental in establishing three highly rated Graduate Programs (Pathology, Toxicology, and Pathophysiology) while he was at the University of Arkansas for Medical Sciences. Because of his academic contribution to UAMS, he was awarded Emeritus Professorship upon his retirement in 2000. After his retirement from academia, Prof. Chang became the Founding Director of the Division of Environmental Health & Occupational Medicine at the National Health Research Institutes in Taiwan in 1999. This Division has specific mission tending to important environmental and occupational health issues in Taiwan. Since its establishment, this Division has become a major research organization of its kind in Taiwan with significant contributions and impacts both in terms of research, education, and service.

As the Founding Director of Div. of Environmental Health & Occupational Medicine at NHRI, Prof. Chang not only excels in personal research achievements but also demonstrates remarkable accomplishments in establishing coordinated teamwork among scientists within his Division and in NHRI as well as collaborative research networks with many distinguished scientists in Taiwan. Prof. Chang is a strong advocate for translational research, joining basic science and clinical research via coordinated teamwork. With the belief that "understanding on disease mechanisms is the first step to solution", Dr. Chang emphasizes strong basic research with objectives on problem solving. Prof. Chang's "4 P" research objectives are: prediction and prevention (intervention) of diseases to achieve protection and promotion of health. This vision and philosophy is the founding corner stones of his Division at NHRI and has providing his Division with the needed mission-oriented purpose on health research in Taiwan.

HONORS & AWARDS

- Golden Forceps Award for best contributions in histological techniques, 1975.
- American Men & Women in Science, 1976.
- Outstanding Young Men of America, 1979.
- Distinguished Leadership & Service Award (Am.-Chinese Toxicology Society), 1989.
- Whos Who in the World, 1994.
- The 20th Century Award of Achievement on Toxicology & Medicine, 1995.
- Who's Who in Sciences & Engineering, 1996.
- Golden Scroll of Excellence in Environmental Health & Toxicology, 1997.
- Fellow, Academy of Toxicological Sciences, 1997.
- Fellow, American Board of Forensic Examiners, 1998.
- Who's Who in Medicine & Healthcare, 1999. International Scientists of the Year, 2003

SELECTED PUBLICATIONS

1. Liao WT, Lin P, Cheng TS, Yu HS, Chang LW. Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells. Toxsicol. Applied Pharmacol. 225, 162-170, 2007
2. Lee HL, Wu JP, Chang LW, Ueng YH, Tsai MF, Hsieh DP, Lin P. Enhancement of metabolic activation of NNK in mouse liver by arsenic. Toxicol. Appl. Pharmacol. (in press), 2007

3. Chang, LW, Chang YC, Ho CC, Tsai MH, Lin P. Increase of carcinogenic risk via enhancement of COX-2 expression and hydroxestrodiol accumulation in human lung cells as a result of interaction between BaP and 17-beta-estradiol. Carcinogenesis 28, 1606-1612, 2007

4. Yang RSH, Chang LW, Wu JP, et.al., Persistent tissue kinetics and redistribution of nanoparticles, Quantum Dot 705, in mice: ICP-MS quantitative assessment. Environ. Perspectives 115, 1339-1343, 2007

5. Cheng, YH, Chang, LW, et al. 4-methoxyestradiol induced oxidative injury in human lung epithelial cells. Toxicol. Appl. Pharmacol. 220, 271-277, 2007

6. Chen SC, Tsai MH, Wang HJ, Yu HS, Chang LW. Involvement of substance P and neurogenic inflammation in arsenic-induced early vascular dysfunction. Toxicol. Sci. 95(1), 82-88, 2007

7. Chao MR, Wang CJ, Yen CC, Yang HH, Lu YC, Chang LW, Hu CW. Simultaneous determination of N7-alkyguanines in DNA by isotop-dilution LC-tandem MS couples with automated solid-phase extraction and its application to a small fish model. Biochemical J. 402, 483-490, 2007

8. Hu CW, Wang CJ, Chang LW, Chao MR. Clinical-scale high throughput analysis of urinary 8-oxo-G by isotope-dilution liquid chromatography-tandem mass spectrometery with on-line solid-phase extraction. Clinical Chemistry 52, 1281-1388, 2006

9. Cheng Y, Chang LW, Tsou TC. Mitogen-activated protein kinases mediated arsenic-induced down-regulation of survival in human lung adenocarcinoma cells. Arch Toxicol. 80 (2), 310-318, 2006

10. Tsou TC, Ysai FY, Yeh SC, Chang LW. ATM/ATR-related checkpoint signals mediated arsenite-induced G2/M arrest in primary aortic endothelial cells. Arch Toxicol. 80, 804-810, 2006

11. Chang FH, Wang HJ, Wang SL, Wang YC, Hsieh DP, Chang LW, Ko YC. Survey of urinary nickel in residents of areas with high density of electroplating factories. Chemosphere 65, 1723-1730, 2006

12. Chang FH, Wang SL, Huang YL, Tsai MH, Yu ST, Chang LW. Biomonitoring of chromium for residents living in areas with a high density of electroplating factories. J. Exposure Analysis & Envir. Epidemiology 16, 138-146, 2006

13. Hu CW, Pan CH, Huang YL, Wu MT, Chang LW, Wang CJ, Chao MR. Effects of arsenic exposure among semiconductor workers: a cautionary note on urinary DNA-adducts. Free Radical Biol. Medicine 40, 1273-1278, 2006

14. Chao MR, Wang CJ, Chang LW, Hu Cw. Qusantitative determination of urinary N7-ethylguanine in smokers and non-smokers using isotope dilution LC/MS/MS with online analyte enrichment. Carcinogenesis 27, 146-151, 2006

15. Chang H, Chang LW*, Cheng YH, Tsai WT, Tsai MX and Lin PP. Preferential Induction of CYP1A1 and CYP1B1 in CCSP-Positive Cells Toxicological Sciences 89(1),205-213, 2006.