Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Shiu-Hwa Yeh, Ph.D.

Assistant Investigator
Institute of Biotechnology and Pharmaceutical Research


Ph.D., Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan, 2005
M.S., Pharmacology, National Cheng Kung University, Tainan, Taiwan, 2000
B.S., Life Science, Tunghai University, Taichung, Taiwan, 1998


Assistant Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health research Institutes, Miaoli, Taiwan (2009-present)
Post-doctoral fellow, Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan (2005-2009)


1. Nervous System Drug Discovery: Opioids are the most effective analgesics in the world, but long-term prescription related addiction and tolerance effects are serious clinical problems. Therefore, it is critical to develop new strategy to control pain that can avoid the adverse effects caused by opioids after prolonged use. Allosteric binding sites on GPCRs are domains topographically distinct from the orthosteric site. Its potential to develop allosteric modulators with greater receptor subtype selectivity. I am interested to find a mu receptor-specific allosteric modifier which will activate the mu receptor without activating delta or kappa receptors. The initial hits are selected by high-throughput screening and hit optimization is operated by medicinal chemistry group. The potential hits are further analyzed for their effects on the mu receptor signaling pathway, pharmacokinetics/pharmacodynamics and animal pharmacology. Our ultimate goal is to identify a new drug allosterically activating MOR for clinical pain management without developing addiction and tolerance effects.
2. Using biochemical, molecular and animal model approaches to investigate the mechanisms of pain, central nervous system injury and neurodegeneration.


2003 The Best Paper Award, the Pharmacological Society in Taiwan.
2004 Best Effort Award, 2004 Annual Research Day, Institute of Basic Medical Sciences, National Cheng Kung University.


Lin, C.H., Yeh, S.H., Lin, C.H., Lu, K.T., Leu, T.H., Chang, W.C., and Gean, P.W., (2001) A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala. Neuron. 31(5): 841-851
Yeh, S.H., Lin, C.H., Lee, C.F., Gean, P.W., (2002) A requirement of nuclear factor-kappa B activation in fear-potentiated startle. J. Biol. Chem. 277(48): 46720-46729
Lin, C.H., Yeh, S.H., Leu, T.H., Chang, W.C., Wang, S.T., and Gean, P.W. (2003) Identification of calcineurin as a key signal in the extinction of fear memory. J. Neurosci. 23(5): 1574-1579
Lin, C.H., Yeh, S.H., Lu, H.Y., and Gean, P.W. (2003) The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory. J. Neurosci. 23(23): 8310-8317
Yeh, S.H., Lin, C.H., Gean, P.W. (2004) Acetylation of nuclear factor-kappa B in rat amygdala improves long-term but not short-term retention of fear memory. Mol. Pharmacol. 65(5): 1286-1292
Yeh, S.H., Mao, S.C., Lin, H.C., Gean, P.W. (2006) Synaptic expression of glutamate receptor after encoding of fear memory in the rat amygdala. Mol. Pharmacol. 69(1): 299-308
Chuang, J.Y., Wang, Y.T., Yeh, S.H., Liu, Y.W., Chang, W.C., Hung, J.J. (2008) Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. Mol. Biol. Cell. 19(3): 1139-1151
Hsiao, Y.H., Chen, P.S., Yeh, S.H., Lin, C.H., Gean, P.W. (2008) N-acetylcysteine prevents ?-amyloid toxicity by a stimulatory effect on the p35/cyclin-dependent kinase 5 activity in cultured cortical neurons. J. Neurosci. Res. 86(12): 2685-2695
Yeh, S.H., Hung, J.J., Gean, P.W., Chang, W.C. (2008) Hypoxia-inducible factor-1? protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression. J. Neurosci. 28(52):14259-14270
Wang, S.A., Chuang, J.Y., Yeh, S.H., Wang, Y.T., Liu, Y.W., Chang, W.C., Hung, J.J. (2009) Heat shock protein 90 is important for Sp1 stability during mitosis. J. Mol. Biol. 387(5): 1106-1119
Ou, L.C., Yeh, S.H., Gean, P.W. (2010) A late expression of brain-derived neurotrophic factor in the amygdala is required for the maintenance of long-term fear memory. Neurobiol. Learn. Mem. 93(3): 372-382

Yeh, S.H., Ou, L.C., Hung, J.J., Gean, P.W., Chang, W.C. (2011) Selective Inhibition of Early- but Not Late-Expressed HIF-1? is Neuroprotective in Rats after Focal Ischemic Brain Damage. Brain pathol. 21(3): 249-262
Yeh, S.H., Gean, P.W., Yang, W.P., Hsu, C.Y., Tseng, J.T., Su, T.P., Chang, W.C., Hung, J.J. (2011) Translational and transcriptional control of Sp1 against ischemia via a hydrogen peroxide-activated IRES pathway. Nuclear Acid Research. 39(13): 5412-5423
Pao, P.C., Huang, N.K., Wang, I.F., Liu, Y.W., Yeh, S.H., Hsieh, Y.T., Huang, H.S., Chang, W.C., Lee, Y.C. (2011) A novel RING finger protein, Znf179, modulates the differentiation of P19 embryonic stem cells to neurons. Cell Death and Differentiation. 18(11): 1791-1804

Hsu, C.C., Lee, Y.C., Yeh, S.H., Chen, C.H., Wu, C.C., Wang, T.Y., Chen, Y.N., Hung, L.Y., Liu, Y.W., Chen, H.K., Hsiao, Y.T., Wang, W.S., Tsou, J.H., Tsou, Y.H., Wu, M.H., Chang, W.C., Lin, D.Y. (2012) The 58-kDa microspherule protein (MSP58) is a novel brahma-related gene 1 (BRG1)-associated protein that modulates the p53-p21 senescence pathway. J Biol Chem. 287(27): 22533-22548