Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Lun Tsou, Ph.D

Assistant Investigator
Institute of Biotechnology and Pharmaceutical Research
kelvintsou@nhri.org.tw

EDUCATION

Ph.D., Chemistry, Yale University, New Haven, CT
B.S., Chemistry-Biochemistry track, and minor in Business Administration, University of North Carolina at Chapel Hill, Chapel Hill, NC

PROFESSIONAL EXPERIENCES

RESEARCH INTERESTS

Chemical Biology

Post-Translational Modifications

Antivirulence and antiviral agents

Protein-Protein interaction inhibitors

SELECTED PUBLICATIONS


1) Tsou, L. K.; Dossa, P. D.; Hang, H. C. ?§Small molecules aimed at type III secretion systems to inhibit bacterial virulence.?? MedChem Comm. 2012, in press.
2) Tsou, L. K.; Cheng, Y.; Cheng, Y. C. ?§Therapeutic development in targeting protein-protein interactions with synthetic topological mimetics.?? Curr Opin Pharmacol. 2012.
3) Tsou, L. K.; Chen, C.H.; Dutschman, G.E.; Cheng, Y.C.; Hamilton, A.D. ?§Blocking HIV-1 entry by a gp120 surface binding inhibitor.?? Bioorg Med Chem Lett. 2012, 22(9), 3358-61
4) Charron, G.; Tsou, L. K.; Maguire, W.; Yount, J. S.; Hang, H. C. ?§Alkynyl-farnesol reporters for detection of protein S-prenylation in cells.?? Molecular BioSystems. 2011, 7(1), 67-73.
5) Yount, J. S.; Tsou, L. K.; Dossa, P. D.; Kullas, A. L.; van der Velden, A. W. M.; Hang, H. C. ?§Visible Fluorescence Detection of Type III Protein Secretion from Bacterial Pathogens.?? J. Am. Chem. Soc., 2010, 132(24), 8244-8245.
6) Zhang, M. M.*; Tsou, L. K.*; Charron, G.; Raghavan, A. S.; Hang, H. C. ?§Tandem fluorescence imaging of dynamic S-acylation and protein turnover.?? Proc. Nat. Acad. Sci. USA. 2010, 107(19), 8627-8632. (*M.M.Z. and L.K.T. contribute equally to this work.)
7) Tsou L. K.; Dutschman G.E.; Gullen E.A.; Telpoukhovskaia M.; Cheng Y.-C.; Hamilton A.D. ?§Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold.?? Bioorg. Med. Chem. Lett. 2010, 20(7), 2137-2139.
8) Cheng, Y.; Tsou, L. K.; Cai, J.; Aya, T.; Dutschman, G. E.; Gullen, E. A.; Grill, S. P.; Chen, A. P.-C.; Lindenbach, B. D.; Hamilton, A. D.; Cheng, Y.-C. ?§A novel class of meso-Tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.?? Antimicrobial Agents and Chemotherapy. 2010, 54(1), 197-206.
9) Tsou, L. K.; Zhang, M. M.; Hang, H. C. ?§Clickable fluorescent dyes for multimodal bioorthogonal imaging.?? Organic & Biomolecular Chemistry. 2009, 7(24), 5055-5058.
10)Margulies, D.; Opatowsky, Y.; Fletcher, S.; Saraogi, I.; Tsou, L. K.; Saha, S.; Lax, I.; Schlessinger, J.; Hamilton, A. D. ?§Surface binding inhibitors of the SCF-KIT protein-protein interaction.?? ChemBioChem, 2009, 10(12), 1955-1958.
11)Jain, Rishi K.; Tsou, L. K.; Hamilton, A. D., ?§Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates.?? Tetrahedron Letters. 2009, 50(23), 2787-2789.
12)Jayawickramarajah, J.; Tagore, D.; Tsou, L. K.; Hamilton, A. D., ?§Allosteric control of self-assembly: Modulating the formation of guanine quadruplexes through orthogonal aromatic interactions??, Angew. Chem. Int. Ed., 2007, 46, 7583-7586.
13)Davis, J. M.; Tsou, L. K.; Hamilton, A. D.: Synthetic non-peptide mimetics of alpha-helices. Chem. Soc. Rev., 2007, 36, 326-334.
14)Park, K. K.; Tsou, L. K.; Hamilton, A. D.: Facile and selective aerobic oxidation of arylalkanes to aryl ketones using cesium carbonate. Synthesis, 2006, 21, 3617-3620.
15)Jain, R. K.; Tsou, L. K.; Hamilton, A. D.: Recognition of Cytochrome C by Tetraphenylporphyrin-based Protein Surface Receptors. Macrocyclic Chemistry, 2005, Kluwer, Editor: Carsten Gloe.
16)Tsou, L. K.; Jain, R. K.; Hamilton, A. D.: Protein surface recognition by porphyrin-based receptors. J. Porph. Phthalocyan. 2004, 8, 141-147.
17)Tsou, L. K.; Tatko, C. D.; Waters, M. L.:A Simple Cation-£k Interaction Between a Phenyl Ring and a Protonated Amine Stabilizes an Alpha-Helix in Water. J. Am. Chem. Soc., 2002, 124, 14917-14921.