Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles

Shin-Ru Shih, Ph.D.

Adjunct Investigator
Institute of Biotechnology and Pharmaceutical Research


  • Ph.D., Molecular Biology and Biochemistry, Rutgers University of New Jersey, U.S.A., 1995
  • M.S., Biochemistry, National Taiwan University, Taiwan, 1991
  • B.S., Medicinal Technology, National Taiwan University, Taiwan, 1988


  • Professor/Chair, Department of Medicinal Biotechnology and Laboratory Science & Medicinal Biotechnology, Chang Gung University (2004-present)
  • Adjunct Investigator, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes (2004-present)
  • Member, Committee of Preparedness for Influenza Pandemic, Department of Health (gov.), Taiwan (2003-present)
  • Medicinal Director, Clinical Virology Laboratory, Chang Gung Memorial Hospital (1999-present)
  • Associate Professor, School of Medical Technology & Institute of Basic Medicine, Chang Gung University (1997-2004)
  • Lecturer, School if Medical Technology, Chang Gung University (1996-1997)
  • Postdoctoral Fellow, Department of Microbiology, Center for Advanced Biotechnology and Medicine of New Jersey, USA (1995-1996)


    Dr. Shin-Ru Shih is dedicated to molecular virology. Her research focuses on Enterovirus 71 and influenza virus.


    The research directions of Dr. Shin-Ru Shihs lab are "Development of diagnostic methods for viral detection," "Establishment of high-through-put screening assay for drug discovery," "Virus cell interaction," and "Reverse Genetics."


  • The Best Poster Presentation Award. The 3rd Chinese Laboratory Medicine Conference, Hong Kong. 1997.
  • Outstanding Research Award. Chang Gung University, Taiwan. 2002.
  • The National Medal for Outstanding Youth. Taiwan. 2004.
    The National Medal for Outstanding Youth. Taiwan. 2004.


    1.Li C, Wang H, Shih SR, Chen TC and Li ML. The efficacy of viral capsid inhibitors in human enterovirus infections and associated diseases. Current Medicinal Chemistry, 14:847-856, 2007.
    2.Chen GW, Shih SR*, Hsiao MR, Chang SC, Sun JF and Tsao KC. Multiple genotypes of influenza B Viruses co-circulated in Taiwan in 2005-2006 season. Journal of Clinical Microbiology, 45(5):1515-1522, 2007. (First and second authors equally contributed)
    3.Chen GW and Shih SR. Influenza A virus PB1-F2 gene [response]. Emerging Infectious Diseases, 12(10): 1207-1209, 2006.
    4.Chung YC, Huang JH, Lai CW, Sheng HC, Shih SR, Ho MS and Hu YC. Expression, purification and characterization of enterovirus-71 virus-like particles. World J Gastroenterol, 12(6):921-7, 2006.
    5.Chen TC, Chen GWu, Hsiung CA, Yang JY, Shih SR, Lai YK and Juang JL. Combining Multiplex Reverse Transcription-PCR and a Diagnostic Microarray To Detect and Differentiate Enterovirus 71 and Coxsackievirus A16. Journal of Clinical Microbiology, 44: 2212-2219, 2006.
    6.Chang SC, Cheng YY and Shih SR (correspondence). Avian influenza virus: the threat of a pandemic. Chang Gung Medical Journal, 29 (2): 130-134, 2006.
    7.Shih SR(correspondence). Recent advances in antiviral agents. Current Pharmaceutical Design, 12(11), 1299-1330, 2006.


  • US Patent US6706739B2 "Imidazolidinone Compounds" Shia KS, Li WT, Chang CM, Hsu MC, Chern JH and Shih SR; granted, 2002.
  • ????????? 203254 ? "??啉????" Shia KS, Li WT, Chang CM, Hsu MC, Chern JH and Shih SR; 2004.
  • ????????? I 281919? "??啉????" Chern JH, Chang CS, Lee CC, Lee YC, Tai CL, Chen CT and Shih SR ; 2007.
  • US Patent US20070049623 A1 "Imidazolidinoe Compounds" Chern JH, Lee CC, Chang CS, Lee YC and Shih SR; granted 2007.