Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Tsai-Ling Yang Lauderdale, Ph.D.

Associate Investigator
Division of Infectious Diseases
lauderdale@nhri.org.tw

EDUCATION

Ph.D., Graduate School of Medicine, Juntendo University, Tokyo, Japan
M.S., Department of Medical Technology specializing in microbiology, State University of New York, Upstate Medical University, USA
B.S., Department of Medical technology, State University of New York, Upstate Medical University, USA

PROFESSIONAL EXPERIENCES

- Associate Investigator, Assistant Investigator, Division of Clinical Research, National Health Research Institutes, Taiwan
- Specialist in Microbiology (SM), American Society for Clinical Pathology, USA
- Medical Technologist/Research Assistant, University of South Alabama, Mobile, AL, USA
- Program Manager, New Hampshire State Public Health Laboratories, Concord, NH, USA
- Research Support Specialist, Diagnostic Laboratory, Cornell University, Ithaca, NY, USA

RESEARCH INTERESTS

Dr. Lauderdale's research interests include phenotypic and genotypic surveillance of antimicrobial resistant bacteria. The main project of her laboratory is the Taiwan Surveillance of Antimicrobial Resistance (TSAR) program, which surveys bacterial pathogens isolated from inpatients and outpatients in Taiwan hospitals. Surveys on resistant bacteria that could be transmitted via the food chain to humans are also conducted. Studies on the molecular epidemiology of and mechanisms of resistance in methicillin resistant Staphylococcus aureus (MRSA), vancomycin resistant enterococci (VRE), and fluoroquinolone resistant bacteria have also been ongoing.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Four rounds of TSAR have been completed since 1998, and the fifth round (TSAR V) is ongoing to provide longitudinal national trends on antimicrobial resistance. Surveillance of resistant bacteria in food animals also provides insight into the potential impact of antimicrobial use in agriculture on human medicine. Recent publications include changes in VRE prevalence in food animals; plasmid mediated fluoroquinolone resistance in a Klebsiella pneumoniae strain; serotype distribution and prevalence of antimicrobial resistance in Salmonella spp. and Streptococcus pneumoniae; and molecular epidemiology of MRSA in Taiwan.

SELECTED PUBLICATIONS

  1. Lauderdale TL*, Shiau YR, Wang HY, Lai JF, Huang IW, Chen PC, Chen HY, Lai SS, Liu YF, Ho M. Effect of banning vancomycin analog avoparcin on vancomycin resistant enterococci in chicken farms in Taiwan. Environ Microbiol. (In press)
  2. Chen YT, Shu HY, Li LH, Liao TL, Wu KM, Shaiu YR, Yan JJ, Su IJ, Tsai SF, Lauderdale TL*. Complete nucleotide sequence of pK245, a 98-kilobase plasmid conferring quinolone-resistance and extended-spectrum b-lactamase activity in a clinical Klebsiella pneumoniae isolate. Antimicrob Agents Chemother. 50:3861-6, 2006.
  3. Lauderdale TL, Wagener MM, Lin HM, Huang IF, Lee WY, Hseih KS, Lai JF, Chiou CC. Serotype and antimicrobial resistance patterns of Streptococcus pneumoniae isolated from Taiwanese children: comparison of nasopharyngeal and clinical isolates. Diagn Microbiol Infect Dis. 56:421-426, 2006.
  4. Lauderdale TL*, Aarestrup FM, Chen PC, Lai JF, Wang HY, Shiau YR, Huang IW, Hung CL, TSAR Hospitals. Multidrug resistance among different serotypes of clinical Salmonella isolates in Taiwan. Diagn Microbiol Infect Dis. 55:149-55, 2006.
  5. Chen FJ, Lauderdale TL*, Huang IW, Lo HJ, Lai JF, Wang HY, Shiau YR, Chen PC, Ito T, Hiramatsu K. Methicillin resistant Staphylococcus aureus in Taiwan. Emerg Infect Dis. 11:1761-3, 2005.
  6. McDonald LC, Lauderdale TL*, Shiau YR, Chen PC, Wang HY, Lai JF, Ho M, TSAR Hospitals. The status of antimicrobial resistance in Taiwan among Gram-positive pathogens: the Taiwan Surveillance of Antimicrobial Resistance (TSAR) Program, 2000. Int J Antimicrob Agents. 23:362-70, 2004.
  7. Lauderdale TL*, McDonald LC, Shiau YR, Chen PC, Wang HY, Lai JF, Ho M. Vancomycin resistant enterococci from humans and retail chickens in Taiwan with unique VanB phenotype-vanA genotype incongruence. Antimicrob Agents Chemother. 46:525-7, 2002.