Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Chi-Ying F. Huang, Ph.D.

Associate Investigator
National Institute of Cancer Research
chiying@nhri.org.tw

EDUCATION

Ph.D., Department of Biochemistry and Biophysics, Iowa State University, USA, 1994
B.S., Department of Chemistry, Tunghai University, Taiwan, 1985

PROFESSIONAL EXPERIENCES

- Associate Investigator, National Institute of Cancer Research, National Health Research Institutes, Taiwan
- Adjunct Associate Professor, Department of Computer Science and Information Engineer, National Taiwan University, Taiwan
- Adjunct Associate Professor, Institute of Biotechnology in Medicine and Institute of Bio-Pharmaceutical Sciences, National Yang-Ming University, Taiwan
- Associate Investigator, Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan
- Assistant Investigator, Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan
- Postdoctoral Fellow, Department of Molecular Pharmacology, Stanford University, USA

RESEARCH INTERESTS

Dr. Huang's research interests are to study the regulatory network of HCC and lung cancer by various functional genomics approaches. They are particularly interested in Aurora-A, a mitotic serine/threonine kinase overexpressed in HCC and lung cancer, mediated signaling through its downstream substrates HURP and CRMP-1.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

To facilitate new approaches, a broad spectrum of systems biology approaches, ranging from microarray, protein chip, and protein-protein interactions, has been utilized in their study to offer a new exploratory modality in the post-genomic era. Two websites, POINT (Prediction Of INTeractomes) (http://point.bioinformatics.tw) and EHCO (Encyclopedia of Hepatocellular Carcinoma genes Online) (http://ehco.iis.sinica.edu.tw) have been created to assist our functional characterization of several novel genes. In addition, they have identified HURP as one of the functional correlated genes of Aurora-A by syn-expression and demonstrated that HURP is a potential oncogenic target of Aurora-A. To reveal the role of Aurora-A in mitosis, they illustrate that Aurora-A-elicited CRMP-1, an invasion suppressor of lung cancer, phosphorylation is to monitor the completion of cytokinesis.

HONORS & AWARDS

- Leukemia Society of America Career Development Award (1998-1999)
- Leukemia Society of America Fellowship (1996-1998)
- Stanford Deans Postdoctoral Fellowship (1994-1995)
- Graduate Research Excellence Award (Iowa State University) (1994)
- The Honor Society of Agriculture (Gamma Sigma Delta) (1989)

SELECTED PUBLICATIONS


  1. Shih-Lan Hsu, Chang-Tze Ricky Yu, Sui-Chu Yin, Ming-Jer Tang, An-Chi Tien, Yi-Mi Wu, and Chi-Ying F. Huang*. Caspase 3, periodically expressed and activated at G2/M transition, is required for nocodazole-induced mitotic checkpoint. Apoptosis 11, 765-771, 2006.

  2. Li-Jen Su, Shih-Lan Hsu, Jyh-Shyue Yang, Huei-Hun Tseng, Shiu-Feng Huang, and Chi-Ying F. Huang. Global gene expression profiling of dimethylnitrosamine induced liver fibrosis: from pathological and biochemical data to microarray analysis. Gene Expression 13, 107-132, 2006.

  3. Jiunn-Chyi Wu, Tzong-Yueh Chen, Chang-Tze R. Yu, Si-Jie Tsai, Jung-Mao Hsu, Ming-Jer Tang, Chen-Kung Chou, Wey-Jinq Lin, Chiun-Jye Yuan and Chi-Ying F. Huang*. Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J. Biol. Chem. 280, 9013-9022, 2005.

  4. Chang-Tze Ricky Yu, Jung-Mao Hsu, Yuan-Chii Gladys Lee, Ann-Ping Tsou, Chen-Kung Chou and Chi-Ying F. Huang. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol. Cell. Biol. 25, 5789-5800, 2005.

  5. An-Chi Tien, Ming-Hong Lin, Li-Jen Su, Yi-Ren Hong, Tai-Shan Cheng, Yuan-Chii G. Lee, Wey-Jinq Lin, Ivan Still, and Chi-Ying F. Huang*. Identification of the substrates and interaction proteins of Aurora kinases from a protein-protein interaction model. Molecular and Cellular Proteomics 3, 93-104, 2004.

  6. Jung-Mao Hsu, Yuan-Chii G. Lee, Chang-Tze R. Yu, and Chi-Ying F. Huang*. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated HURP proteolysis by proline-rich region. J. Biol. Chem. 279, 32592-32602, 2004.

  7. Tao-Wei Huang, An-Chi Tien, Wen-Shien Huang, Yuan-Chii G. Lee, Chin-Lin Peng, Huei-Hun Tseng, Cheng-Yan Kao, and Chi-Ying F. Huang*. POINT: a database for the prediction of protein-protein interactions based on the orthologous interactome. Bioinformatics 20, 3273-3276, 2004.