Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Hsing-Pang Hsieh, Ph.D.

Investigator/Associate Director

hphsieh@nhri.org.tw

EDUCATION

Ph.D., Organic Chemistry, State University of New York (1993)
M.S., Organic Chemistry, National Tsing Hua University (1987)
B.S., Chemistry, National Tsing Hua University (1985)

PROFESSIONAL EXPERIENCES

  • Investigator, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes. (2007 - present)
  • Adjunct Associate Professor, Department of Chemistry, National Tsing Hua University. (2003 - present)
  • Associate Investigator, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes. (2003 - 2007)
  • Assistant Investigator, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes. (1998-2002)
  • Visiting Scholar, Shionogi BioResearch Corp., USA. (Mar-June 1999)
  • Post-Doctoral Fellow, Institute of Biological Chemistry, Academia Sinica. (1997-1998)
  • Research Associate, Department of Chemistry, Boston College, USA. (1994-1995)

    RESEARCH INTERESTS

    Dr. Hsieh's research interests are deeply involved in three different areas, namely cancer, infectious diseases, and diabetes. In particular, tubulin and kinase are mainly two drug targets for cancer research. Five antiviral projects, including anti-hepatitis B virus (HBV), anti-human cytomegalovirus (HCMV), anti-hepatitis C virus (HCV), anti-SARS, and anti-flu projects and two antidiabetes projects including Peroxisome Proliferator- Activated Receptors (PPARs) agonists and dipeptidylpeptidase 4 (DPP4) inhibitors are also involved in.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Hsieh has published 50 papers in peer reviewed international journals, including 12 papers in J. Med. Chem., which ranks number one in medicinal chemistry journals and co-inventor in more than twenty-five DBPR patent applications, including one US patent (US6933316) granted. Most importantly, the work resulted in discovery of anticancer drug candidate, DBPR104, which is currently under preclinical development and expected to file an Investigational New Drug (IND) Application in 2008.

    HONORS & AWARDS

  • 2006 NHRI Young Scientist Award
  • NSC Research Funding Principal Investigator (2006/8-2009/7)
  • NSC Anti-Flu Research Funding Co-PI (2006/8-2009/7)
  • NSC Research Funding Principal Investigator (2005/8-2006/7)
  • NSC Anti-SARS Research Funding Co-PI (2004/7-2005/6)
  • NSC Anti-SARS Research Funding Co-PI (2003/7-2004/6)

    SELECTED PUBLICATIONS

    1.Mahindroo N, Hsieh H P*, et al. Structural Basis for the Structure-Activity Relationships of Peroxisome Proliferator-Activated Receptor Agonists. J. Med. Chem., 49: 6421-6424, 2006. (*=Corresponding Author)

    2.Mahindroo N, Hsieh HP*, et al. Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists Design, Synthesis, Structural Biology, and Molecular Docking Studies. J. Med. Chem., 49:1212-1216, 2006. (*=Corresponding Author)

    3.Mahindroo N, Hsieh HP*, et al. Novel Indole-based Peroxisome Proliferator-Activated Receptors Agonists: Design, SAR, Structural Biology and Biological Activities. J. Med. Chem., 48:8194-8208, 2005. (*=Corresponding Author)

    4.Liou JP, Hsieh HP*, et al. Concise Synthesis and Structure-Activity Relationships of Combretastatin A-4 Analogues, 1-Aroylindoles and 3-Aroylindoles, as Novel Classes of Potent Antitubulin Agents. J. Med. Chem., 47:4247-4257, 2004. (*=Corresponding Author)

    5.Kuo CC, Hsieh HP, Chang JY*, et al. BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo. Cancer Res., 64:4621-4628, 2004. (*=Corresponding Author)

    6.Liou JP, Mahindroo N, Hsieh HP*, et al. Synthesis and Structure-Activity Relationship of 3-Aminobenzophenones as Antimitotic Agents. J. Med. Chem., 47:2897-2905, 2004. (*=Corresponding Author)

    7.Liou JP, Hsieh HP*, et al. Synthesis and Structure-Activity Relationship of 2-Aminobenzophenone Derivatives as Antimitotic Agents. J. Med. Chem., 45:2556-2562, 2004. (*=Corresponding Author)

    PATENT

    1.US6933316 "Indole Compounds": August 23, 2005.
    2.US5610149 "Steroidal Polyamines": 1997.