Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Jeng-Jiann Chiu, Ph.D.

Investigator
Division of Medical Engineering Research
jjchiu@nhri.org.tw

EDUCATION

Ph.D., Fluid Mechanics, Institute of Aeronautics and Astronautics, National Cheng-Kung University, Taiwan, ROC.

PROFESSIONAL EXPERIENCES

  • Official Member of the Working Group of Cellular Engineering, the International Federation for Medical and Biological Engineering (IFMBE) (2007-present)
  • Secretary-general of The Chinese Society of Cell and Molecular Biology, Taiwan (2007-present)
  • Official Member of Review Committee (Medical Engineering Session) of Department of Engineering and Applied Sciences, National Science Council, Taiwan (2007-present)
  • Associate Investigator, Division of Medical Engineering Research, National Health Research Institutes, Taiwan (2004-present)
  • Joint-Appointment Associate Professor, Institute of Biomedical Engineering, National Yang-Ming University, Taiwan (2003- present)
  • Assistant Investigator, Division of Medical Engineering Research, National Health Research Institutes, Taiwan (2000-2004)
  • Adjunct Associate Professor, Graduate Institute of Life Sciences, National Defense Medical Center, Taiwan (1999-present)
  • Postdoctoral Research Fellow, Division of Cardiovascular Research, Institute of Biomedical Sciences, Academia Sinica, Taiwan (1993- 2000)

    RESEARCH INTERESTS

    Dr. Chiu has been characterized as a bioengineer equipped with a broad academic background of multi-disciplines in vascular biology, cellular and molecular biology, experimental biology, fluid mechanics, and tissue engineering. His research goal is to elucidate the molecular mechanisms of the regulation of vascular functions, with a special emphasis on the transduction of mechanical stimuli, such as blood flowinduced shear stress, into intracellular signaling and the ensuing gene expression and functional responses in health and disease. A multidisciplinary, integrative approach is used that combines engineering and biomedical sciences, including nanotechnology, DNA microarrary, bioinformatics, cell biophysics, biomechanics, and ex vivo and in vivo research on cardiovascular system. The results are related to clinical problems such as atherosclerosis, gene therapy, and functional tissue engineering.

    RESEARCH ACTIVITIES & ACCOMPLISHMENTS

    Dr. Chiu has conducted innovative researches on the effects of shear stress on interactions of vascular endothelial cells and smooth muscle cells, as well as circulating leukocytes. He established a new experimental model for the study of the effects of flow-induced shear stress on co-cultures of endothelial cells and smooth muscle cells, with the capability of performing live microscopic studies under dynamic states, including the imposition of various patterns of flow. With a series of original and elegant experiments, Dr. Chiu has shown that the co-culture of endothelial cells with smooth muscle cells induces the expression of various adhesion molecules and chemokines in endothelial cells and enhances the adhesion of circulating leukocytes to endothelium. These co-culture induced effects are mediated by various flow patterns and are inhibited by the application of laminar shear stress, and Dr. Chiu demonstrated that the anti-inflammatory action of laminar shear stress is mediated through modulating endothelial gene expression. These results made major contributions to the understanding of the interactions among blood cells, endothelial cells, and smooth muscle cells; no one has ever succeeded in studying these complicated interactions, especially under various flow patterns. Dr. Chius ground-breaking findings not only have elucidated the molecular and cell biological bases of mechanotransduction, but also have significant implications in the understanding of the interplays between cellular/molecular and mechanical factors in the modulation of inflammatory state and atherogenesis of the vasculature. Such findings have important bearings on a variety of key clinical disorders such as myocardial infarction, stroke and intermittent claudication.

    HONORS & AWARDS

  • TienTe Lee Award - Young Scientist. TienTe Lee Biomedical Foundation, 2007.
  • The Academia Sinica Young Investigator Research Award, Academia Sinica, 2007.
  • TienTe Lee Award - The Best Thesis (to the corresponding Ph.D. student Mr. Cheng-Nan Chen). TienTe Lee Biomedical Foundation, 2007.
  • The Distinguished Research Award, National Science Council, 2006
  • The Young Investigator Outstanding Research Achievement Award. National Health Research Institutes, 2006.
  • The First Prize of Dr. Chien-Tien Hsu's Science Award (to the corresponding Ph.D. student Mr. Cheng-Nan Chen). The Chinese Society of Cell and Molecular Biology, 2006.
  • The Most Outstanding Research Presentation Award (to the corresponding Ph.D. student Mr. Shun-Fu Chang). The 7th Engineering Technology and Appplication of Chinese and Western Medicine Meeting, 2004.
  • Research Award. National Science Council, 1994, 1997-1999.
  • The Best Ph.D. Thesis Award. Li-Ching Culture and Education Foundation, 1992.

    SELECTED PUBLICATIONS

    1.Chang SF, Chang CA, Lee DY, Lee PL, Yeh YM, Yeh CR, Cheng CK, Chien S and Chiu JJ*. Tumor cell cycle arrest induced by shear stress: roles of integrins and Smad. Proc Natl Acad Sci U S A (Accepted, 2008)
    2.Chiu JJ*, Chen LJ, Lee CI, Lee PL, Tasi MC, Lee DY, Usami S and Chien S. Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress. BLOOD, 110:519-528, 2007.
    3.Chen CN, Li JY, Yeh YT, Lee PL, Usami S, Chien S and Chiu JJ*. Synergistic roles of platelet-derived growth factor-BB and interleukin-1? in phenotypic modulation of human aortic smooth muscle cells. Proc Natl Acad Sci U S A, 103:2665-2670, 2006.
    4.Chen CN, Chang SF, Lee PL, Chang K, Chen LJ, Usami S, Chien S and Chiu JJ*. Neutrophils, lymphocytes, and monocytes show differential behaviors of transendothelial and subendothelial migrations under co-culture with smooth muscle cells and disturbed flow. BLOOD, 107:1933-1942, 2006.
    5.Chiu JJ*, Chen LJ, Chang SF, Lee PL, Lee CI, Tasi MC, Lee DY, Hsieh HP, Usami S and Chien S. Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells: Role of NF-?B. Arterioscler Thromb Vasc Biol, 25:963-969, 2005.
    6.Chiu JJ*, Lee PL, Chen CN, Lee CI, Chang SF, Chen LJ, Lien SC, Ko YC, Usami S and Chien S. Shear stress increases ICAM-1 and decreases VCAM-1 and E-selectin expressions induced by tumor necrosis factor-? in endothelial cells. Arterioscler Thromb Vasc Biol, 24:73-79, 2004.
    7.Chiu JJ*, Chen LJ, Lee PL, Lee CI, Lo LW, Usami S and Chien S. Shear stress inhibits adhesion molecule expression in vascular endothelial cells induced by co-culture with smooth muscle cells. BLOOD, 101:2667-2674, 2003.