Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Ming-Chao Lin, Ph.D.

Assistant Investigator
Division of Medical Engineering Research
klin@nhri.org.tw

EDUCATION

-Ph.D., Bioengineering, University of California, San Diego, USA, 1998
-B.S., Mechanical Engineering, National Taiwan University, Taiwan, 1991

PROFESSIONAL EXPERIENCES

- Joint-appointed Assistant Professor, Institute of Biomedical Engineering, National Yang Ming University, Taiwan (2003- present)
- Assistant Investigator, Division of Medical Engineering Research, National Health Research Institutes, Taiwan (2001 -present)
- Postdoctoral Fellow, Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, USA (1998- 2001)

RESEARCH INTERESTS

Dr. Lin's research interests include the following:
1. Inducible transgenic models and developing multimodal molecular imaging tools to be applied in a variety of disciplines, including cancer and inflammatory diseases
2. Regulatory roles of the stretching force in cell/tissue/organ development

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Lin focuses on translational research of developing conditional transgenic mouse models (Cre mice and LoxP mice) and multimodal imaging reporter genes. He has set up the molecular imaging and transgenic research laboratory to establish in-house capability of animal experiments, animal models, imaging acquisition, and imaging analysis in medical engineering research division. Dr. Lin's team has developed the imaging reporter genes for bioluminescence, fluorescence, nuclear imaging, and magnetic resonance imaging. He also developed breast and liver tumor models to prove the functionality of tumor cells expressing multimodal reporter genes. Lins lab has a long-term theme as exploring the roles of mitochondrial heat shock proteins (hsp60, hsp10, and mthsp70) in CV diseases and cancers. The current approaches include the use of inducible transgenic mouse models.

SELECTED PUBLICATIONS

  1. Lin K, Hollander JM, Kao V, Lian I, Lin B, Dillmann WH Protection of rat neonatal cardiac myocytes death by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of Ras GTP-ase pathway. FASEB J. 10.1096/fj.03-0348fje, 2004.
  2. Hollander JM, Lin K, Scott B, Dillmann WH Overexpression of PHGPx and HSP60/10 Protects against Ischemia/Reoxygenation Injury. Free Radical Biology & Medicine 35(7):742-751, 2003.
  3. Das DK, Dillmann W, Ho YS, Lin KM, Gloss BR. Using genetically engineered mice to study myocardial ischemia-reperfusion injury. Methods Enzymol 353:346-65, 2002.
  4. Lin K, Lin B, Lian I, Mestril R, Scheffler I, Dillmann WH Combined and individual mitochondrial HSP60 and HSP10 expression in cardiac myocytes protects mitochondrial function and prevents apoptotic cell deaths induced by simulated ischemia-reoxygenation. Circulation 103:1787-1792, 2001.
  5. Lin K, Hsu PP, Chen BP, Yuan S, Usami S, Shyy JY, Li YS, Chien S Molecular mechanism of endothelial growth arrest by laminar shear stress. Proc Natl Acad Sci U S A. 97(17):9385-9, 2000.
  6. Lin M, Almus-Jacobs F, Chen H, Parry GC, Mackman N, Shyy JY, chien S Shear stress induction of the tissue factor gene. J. Clin. Invest. 99(4):737-44, 1997.
  7. Shyy JY, Lin MC, Han J, Lu Y, Petrime M, Chien S The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proc Natl Acad Sci U S A. 92(17):8069-73, 1995.