Faculty Profile, National Health Research Institutes, Taiwan

Faculty Profiles


Jen-Yang Chen, Ph.D.

Distinguished Investigator and Deputy Director
National Institute of Cancer Research
cjy@nhri.org.tw

EDUCATION

Ph.D., Medical Microbiology, London University, England, 1988
M.S., Microbiology, National Taiwan University, Taiwan, 1972
B.Sc., Entomology, National Taiwan University, Taiwan, 1968

PROFESSIONAL EXPERIENCES

  • Deputy Director, National Institute of Cancer Research, National Health Research Institutes, Taiwan (2006-present)

  • Distinguished Investigator, National Institute of Cancer Research, National Health Research Institutes, Taiwan (2006-present)

  • Acting Director, Extramural Research Affairs Department, National Health Research Institutes, Taiwan (2006)

  • Consultant, Office of Science and Technology Development, Department of Health, Taiwan (2001-2003)

  • Director, Extramural Research Affairs Department, National Health Research Institutes, Taiwan (1996-2005)

  • Chairman, Department of Microbiology, College of Medicine, National Taiwan University, Taiwan (1988-1993)

  • Professor, Department of Microbiology, College of Medicine, National Taiwan University, Taiwan (1987-2002)

  • Associate Professor, Department of Microbiology, College of Medicine, National Taiwan University, Taiwan (1981-1987)

  • Visiting Scholar, Department of Pharmacology, University of North Carolina, Chapel Hill, USA (1979-1980)

  • Visiting Scientist, Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo, New York, USA (1978-1979)

  • Lecturer, Department of Microbiology, College of Medicine, National Taiwan University, Taiwan (1973-1981)

  • Teaching Assistant, Department of Microbiology, College of Medicine, National Taiwan University, Taiwan (1968-1973)

RESEARCH INTERESTS

Dr. Chen's research interests include studies on the role of Epstein-Barr virus (EBV) plays on the carcinogenesis of nasopharyngeal carcinoma (NPC) and the development of markers for the diagnosis of the disease.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Chen has authored 130 original articles. He has studied the feasibility of several antibodies against EBV as markers for the diagnosis of NPC. Using these markers, through retrospective, case control, and prospective studies, his research group has demonstrated that EBV plays an etiological role in the carcinogenesis of NPC. Dr. Chen is a reviewer for numerous journals. He is also a member in editorial boards of several scientific journals.

HONORS & AWARDS

  • Outstanding Merits Award, National Science Council, Taiwan (2004)

  • Merits Award, National Science Council, Taiwan (1998-2004)

  • Outstanding Research Award, National Science Council, Taiwan (1992-1998)

  • Outstanding Teacher Award, Ministry of Education, Taiwan (1986)

SELECTED PUBLICATIONS

  1. Li LY, Liu MY, Shih HM, Tsai CH and Chen JY. Human cellular protein VRK2 specifically interacts with Epstein-Barr virus BHRF 1, a homologue of Bc1-2, and enhances cell survival. Journal of General Virology, 87:2869-2878, 2006.

  2. Wu CC, Hsu TY and Chen JY. Characterication of three essential residues in the conserved ATP-binding region of Epstein-Barr virus thymidine kinase. Biochemistry, 44:4785-4793, 2005.

  3. Liu MT, Chang YT, Chen SC, Chuang YC, Chen YR, Lin CS and Chen JY. Epstein-Barr Virus latent membrane protein 1 represses p53-mediated DNA repair and transcriptional activity. Oncogene, 24:2635-2646, 2005.

  4. Wu CC, Chen MC, Chang YR, Hsu TY and Chen JY. Identification and characterization of the conserved nucleoside binding sites in the Epstein-Barr virus thymidine kinase. Biochemical Journal, 379:795-803, 2004.

  5. Liu MT, Chen YR, Chen SC, Hu CY, Lin CS, Chang YT, Wang WB and Chen JY. Epstein-Barr virus latent membrane protein 1 induces micronucleus formation, represses DNA repair and enhances sensitivity to DNAdamaging agents in human epithelial cells. Oncogene, 23:2531-2539, 2004.

  6. Liu MT, Hu HP, Hsu JY and Chen JY. Site directed mutagenesis in a conserved motif of Epstein-Barr virus DNase that is homologous to the catalytic center of type II restriction endonucleases. Journal of General Virology, 84:677-686, 2003.

  7. Li LY, Shih SM, Liu MY and Chen JY. The cellular protein PRA1 modulates the antiapoptotic activity of Epstein-Barr virus BHRF1, a homologue of Bc1-2, through direct interaction. Journal of Biological Chemistry, 276:27354-27362, 2001.